Healthspan is the first online medical clinic dedicated to fighting age-related diseases and increasing human performance by fighting cellular senescence.
Jun 10 • 12 tweets • 2 min read
1. Elite endurance athletes spend roughly 80% of training time below lactate threshold and 20% well above it.
This distribution isn't arbitrary—it reflects a fundamental asymmetry in how different training intensities drive mitochondrial biogenesis versus capillary expansion.
The gray zone between them produces neither adaptation efficiently. 🧵
2. A meta-analysis of nearly 6,000 participants examined how training intensity influenced mitochondrial content and capillary density.
All three intensities—endurance, high-intensity intervals, and sprint training—increased mitochondrial content by ~25%.
But capillary density responded differently.
Dec 26, 2023 • 31 tweets • 5 min read
1. People with chronic inflammatory conditions have continuously overactive immune systems.
Low-dose naltrexone (LDN) appears to reduce this out-of-control inflammation.
How?
We delve into how LDN modulates our immune and neuroimmune reactions to fight inflammation.
LG! 🧵👇
2. Chronic inflammation lies at the core of numerous debilitating diseases, from autoimmune disorders to neurodegenerative conditions.
While acute inflammation serves a protective purpose, chronic inflammation leads to tissue dysfunction and the acceleration of aging.
Nov 26, 2023 • 31 tweets • 5 min read
1. People with chronic inflammatory conditions have continuously overactive immune systems.
Low-dose naltrexone (LDN) appears to reduce this out-of-control inflammation.
How?
We delve into how LDN modulates our immune and neuroimmune reactions to fight inflammation.
LG! 🧵👇
2. Chronic inflammation lies at the core of numerous debilitating diseases, from autoimmune disorders to neurodegenerative conditions.
While acute inflammation serves a protective purpose, chronic inflammation leads to tissue dysfunction and the acceleration of aging.
Nov 19, 2023 • 43 tweets • 7 min read
1. @Blagosklonny's theory of cellular hyperfunction has shifted our understanding of aging.
The theory states that aging is not a result of cellular decline or damage accumulation but rather excessive cellular activity he calls hyperfunctions.
Here's how it works 👇
2. Traditionally we have believed that aging results from wear and tear and the gradual loss of cellular function.
This understanding has been rooted in the idea that living organisms have a limited ability to repair themselves, leading to the accumulation of damage over time.
Oct 29, 2023 • 43 tweets • 7 min read
1. @Blagosklonny's theory of cellular hyperfunction has shifted our understanding of aging.
The theory states that aging is not a result of cellular decline or damage accumulation but rather excessive cellular activity he calls hyperfunctions.
Here's how it works 👇
2. Traditionally we have believed that aging results from wear and tear and the gradual loss of cellular function.
This understanding has been rooted in the idea that living organisms have a limited ability to repair themselves, leading to the accumulation of damage over time.
Oct 16, 2023 • 37 tweets • 6 min read
1. Rapamycin paradoxically suppresses immune function when taken daily at high doses.
When taken cyclically at low doses, it enhances it.
How do mTOR inhibitors like rapamycin may enhance immune function?
The research of @MannickJoan is critical to understanding how.
LG 🧵👇
2. The mTOR pathway regulates cell growth. Its dysregulation drives cellular dysfunction and the acceleration of aging.
As we age, mTOR may stay active all the time—opening the door to out-of-control cell growth that can lead to cancer and closing the door on cell repair.
Sep 12, 2023 • 43 tweets • 7 min read
1. @Blagosklonny's theory of cellular hyperfunction has shifted our understanding of aging.
The theory states that aging is not a result of cellular decline or damage accumulation but rather excessive cellular activity he calls hyperfunctions.
Here's how it works 👇
2. Traditionally we have believed that aging results from wear and tear and the gradual loss of cellular function.
This understanding has been rooted in the idea that living organisms have a limited ability to repair themselves, leading to the accumulation of damage over time.
Jul 21, 2023 • 37 tweets • 6 min read
1. Rapamycin paradoxically suppresses immune function when taken daily at high doses.
When taken cyclically at low doses, it enhances it.
How do mTOR inhibitors like rapamycin may enhance immune function?
The research of @MannickJoan is critical to understanding how.
LG 🧵👇
2. The mTOR pathway regulates cell growth. Its dysregulation drives cellular dysfunction and the acceleration of aging.
As we age, mTOR may stay active all the time—opening the door to out-of-control cell growth that can lead to cancer and closing the door on cell repair.
Jul 9, 2023 • 43 tweets • 7 min read
1. @Blagosklonny's theory of cellular hyperfunction has shifted our understanding of aging.
The theory states that aging is not a result of cellular decline or damage accumulation but rather excessive cellular activity he calls hyperfunctions.
Here's how it works 👇
2. Traditionally we have believed that aging results from wear and tear and the gradual loss of cellular function.
This understanding has been rooted in the idea that living organisms have a limited ability to repair themselves, leading to the accumulation of damage over time.
Jun 20, 2023 • 43 tweets • 9 min read
1. @Blagosklonny's theory of cellular hyperfunction has shifted our understanding of aging.
The theory states that aging is not a result of cellular decline or damage accumulation but rather excessive cellular activity he calls hyperfunctions.
Here's how it works 👇
2. Traditionally we have believed that aging results from wear and tear and the gradual loss of cellular function.
This understanding has been rooted in the idea that living organisms have a limited ability to repair themselves, leading to the accumulation of damage over time.
