Hilary Robbins Profile picture
Epidemiologist at @IARCWHO. Cancer screening researcher, denominator police. She/her. Views my own.
Feb 27, 2020 6 tweets 3 min read
The all-cause mortality result in the NELSON #lungcancer screening trial has generated major debate.

How do we interpret this? Let's start with what we expected to observe.

@NEJM #lcsm #lungcancerscreening #EpiTwitter NELSON showed a 24% statistically significant reduction in lung cancer mortality with low-dose CT screening in men.

If the intervention (screening) does not lead to fatal harms, then we expect the rate of death from other (non-lung-cancer) causes to be the same in both arms.