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Stephen Conn (he/him) Profile picture
Stephen Conn (he/him)
@holympus
former startup person, current medical student, forever gay. lgbtq health, harm reduction, death/dying, equity in medicine, technology. tweets/opinions my own
Mar 3, 2022 • 15 tweets • 5 min read
🧵tweetorial time!

why can naloxone be given intranasally to reverse overdose, when naloxone commonly found in sublingual forms of buprenorphine does not absorb across the buccal mucosa?

usual reminders: i am not an expert and this thread is for learning!

ok, let's go!

1/x 1⃣ the first difference is the mucosa itself--as much as i hate anatomy, it's time for a quick review! citations appear at the end of the tweetorial.

the nasal epithelium has three main regions, pictured below in dark, medium, and pale yellow:

2/x
 (veronesi et al 2020) Image