Dr. Jay Wrigley Profile picture
Functional Medicine Doctor | I fix metabolic & hormonal issues with obesity, peri/menopause, men’s health, thyroid function, digestive function & more.
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Nov 20 9 tweets 2 min read
The idea that autoimmune diseases have their root cause in the gut is a widely discussed concept in functional & integrative medicine. While autoimmune diseases are complex, there is strong evidence that gut health plays a significant role in their development & progression The Gut-Immune Connection

The Gut as the Immune System’s Hub:
Around 70-80% of the immune system is located in the gut, where the intestinal lining & microbiome play critical roles in regulating immune function

The gut acts as a barrier, preventing harmful substances (e.g., toxins, pathogens) from entering the bloodstream. A compromised gut lining leads to immune dysregulation
Oct 6 14 tweets 3 min read
Statins & their relationship to the coenzyme CoQ10

Statin drugs, prescribed to lower cholesterol work by inhibiting an enzyme called HMG-CoA reductase, the key to the Mevalonate pathway that produces both cholesterol & (CoQ10)

#Statins cause CoQ10 depletion & this is dangerous Mechanism of Statins & CoQ10 Depletion

Inhibition of HMG-CoA Reductase: Statins (such as atorvastatin, simvastatin, and rosuvastatin) block the activity of HMG-CoA reductase, the enzyme that converts HMG-CoA into mevalonate. 1st step in the production of #cholesterol
Apr 25, 2023 8 tweets 3 min read
Menopause can result in a decline in hormone levels, including testosterone, which is essential for various aspects of a woman's health. Here are some natural ways a menopausal woman can increase her testosterone levels: #menopause #testosterone Exercise & physical activity: Regular exercise, particularly strength training & high-intensity interval training (HIIT), have shown to raise testosterone levels. Incorporate a mix of cardio & resistance training exercises into your routine to help maintain healthy hormone levels
Feb 20, 2023 15 tweets 5 min read
Keys to successful fat loss:

Get some momentum going as quick as possible. Once seeing progress, it's hard to want to sabotage that

Eat 2 primary meals a day about 6-7 hours apart. Let I.F. work for you

First meal of the day should be heavy in protein & good fat=Satiety pic# 1 Image Last meal of the day should be high protein, lower in fat & around 30-50gms of carbohydrate for optimal hormonal signaling & conversion. Picture #2

If you need to eat between the 6-7 hour window, make it moderate in protein, moderate in fat & low in carbohydrate. Picture #3 ImageImage
May 29, 2022 7 tweets 2 min read
1/7 Leptin has been firmly established as the essential hormone for the maintenance of energy homeostasis and body weight, and leptin resistance has been widely recognized as the key risk factor for obesity. Leptin promotes weight loss primarily by activating the LEPRb pathways 2/7 in the brain, particularly in the hypothalamus. To provide the most comprehensive support for weight management, you need more than the standard metabolic health support. Special attention should be paid to the endocrine aspects of metabolism and appetite - in addition to
May 17, 2022 4 tweets 1 min read
1/4 This is straight from Ray Peat, PHD
Few on the planet have his understanding of this situation.
Estrogen blocks the release of hormone from the thyroid gland, and progesterone facilitates the release. Estrogen excess or progesterone deficiency tends to cause enlargement 2/4 of the thyroid gland, in association with a hypothyroid state. Estrogen can activate the adrenals to produce cortisol, leading to various harmful effects, including brain aging and bone loss. Progesterone stimulates the adrenals and the ovaries to produce more progesterone,
Oct 11, 2019 4 tweets 1 min read
1/4 How do seed oils cause hormonal imbalances?

There are many changes in hormones caused by unsaturated fats. Their best understood effect is their interference with the function of the thyroid gland. Unsaturated oils block thyroid hormone secretion, its movement in the 2/4
circulatory system, and the response of tissues to the hormone. When the thyroid hormone is deficient, the body is generally exposed to increased levels of estrogen. The thyroid hormone is essential for making the "protective hormones" progesterone and pregnenolone,