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Lu Chen #noCoffee Profile picture
Lu Chen #noCoffee
@houndcl
Recursionaut @RecursionPharma. Former NCATSian @ncats_nih_gov Making every data point count. More than a data scientist. Husband & Dad. ∀opinion ∈ {me}. He/him.
May 7, 2020 • 9 tweets • 4 min read
Let’s talk about the zinc. This supplement has gone viral together with #hydroxychloroquine and #azithromycin hype, and has been promoted without scientific evidence.
thread🔻
Most Zinc supporter refer to this article published on PLoS Pathogen in 2010, which described an in vitro inhibitory effect of Zn against SARS-CoV. Author also suggests the RdRp-dependent potential mechanism. Can this be translated to SARS-CoV-2? Let’s dive in. Image
Apr 25, 2020 • 8 tweets • 4 min read
a "highly-(self)-cited" preprint from #raoult suggesting in vitro synergy of #hydrodroxychloroquine + #azithromycin against SARS-CoV-2 got accepted by Microbial Pathogenesis.

sciencedirect.com/science/articl…

a 18-day "serious" peer review happened

Let's see what we have(troll face)🔻 This paper is more like a beautiful mathematic proof - concise but "brilliant" -

"we proved that synergy is true. period"

Abstract: 93 words
Result: 143 words

🤣🤣🤣
Apr 13, 2020 • 22 tweets • 5 min read
Having seen so many double standards on #remdesivir and #hydroxychloroquine result, I decide to start a thread to share how I read a scientific paper.

While I only expect 1% people who finally adopt the protocol, I do hope scientists and famous writers have a try.

thread🔻 (1/) Links:
Remdesivir (NEJM)
nejm.org/doi/full/10.10…

Hydroxychloroquine + azithromycin (preprint)
mediterranee-infection.com/pre-prints-ihu/
Apr 12, 2020 • 12 tweets • 5 min read
(1/) An update of analysis of Dr. Raoult’s #hydroxychloroquine #azithromycin trial on 1061 patients.
mediterranee-infection.com/pre-prints-ihu/
(warning: it’ more like conspiracy theory) (2/) Actually the preprints have two versions.

“Version 2”
mediterranee-infection.com/wp-content/upl…

Final version
mediterranee-infection.com/wp-content/upl…

There're minor changes in the final version compared to v2. Most are Ct values and HCQ serum concentrations. Other baseline characteristics are the same.
Apr 9, 2020 • 12 tweets • 5 min read
(1/n) Raoult’s team reported the result of hydroxychloroquine + azithromycin trial to treat COVID19 for > 1k patients.

mediterranee-infection.com/wp-content/upl…

mediterranee-infection.com/wp-content/upl…

Once again, data is broken, and I smelled their anxiety several days ago.


Threads🔻 (2/n) I closely monitor IHU’s COVID-19 website since the birth on 3/26.

mediterranee-infection.com/covid-19/

This website reports the number of COVID positives & death in APHM/IHU, and num of positives & death with >3d treatment. Some major discrepancies have been found.

website data: