Have you ever wished to sequence SPECIFIC bacteria but NOT the vast background in #microbiome? Today, we introduce *mEnrich-seq*: #methylation-guided enrichment sequencing of bacterial taxa of interest from microbiome. 4yr project led by @clannabel7! biorxiv.org/content/10.110…🧵1/10 #Metagenomic sequencing throughput is largely consumed by abundant microbes while those with relatively lower abundance cannot be sequenced in a cost-effective manner, due to the highly skewed abundance distribution of diverse bacteria and host DNA. 2/10