Research Group Leader at EMBL-EBI @emblebi. @CR_UK Career Establishment Awardee. Cancer genomics.
Nov 24, 2022 • 21 tweets • 8 min read
We are most happy to present SComatic, an algorithm for de novo detection of somatic mutations in high-throughput single-cell data, including single-cell RNAseq and ATAC-seq. Monumental effort led by @fran_muyasbiorxiv.org/content/10.110… Thread 👇
Context: detecting somatic mutations in single cells is critical to study somatic evolution, cell plasticity, cancer and clonal mosaicism. However, identifying mutations at single-cell resolution is challenging due to various types of artefacts (allelic imbalances, etc).