There is so much wrong with @bryan_johnson's blood test results - that if you told me that it was just a regular individual who doesn't do any health interventions (let alone spending millions of dollars a year), I'd honestly believe it.

I'll unpack it all below:

https://twitter.com/bryan_johnson/status/1912215150784049207

Firstly, his cholesterol is ridiculously low - which is not a good thing, btw.

Cholesterol is needed for:
-Hormones
-Bile acids
-Myelin sheath
-Cell membranes
-Vitamin D
-And much more.

His triglycerides are low by nature of lower cholesterol.

Only positive here is that he has higher HDL relevant to LDL - but there's a lot of nuance when it comes down to particle size and inflammation.

Most supplements are single-use and overpriced.

One for gut, one for energy, one for stress...

But there's one that does it all - it's multi-purpose.

It's called Black Seed Oil.
A cure for everything but death.

Here's everything it does (+ how to use it properly): 🧵 Black seed oil, known traditionally as Nigella sativa oil, is one of the most potent multifaceted natural medicines in human history.

For centuries, it has been used across Africa, the Middle East, and Asia for a broad range of chronic and acute issues.

If there's a beneficial function found in a supplement, you can almost bet that black seed oil is also capable of doing that.

When we look at hair loss under the term energetic alopecia, we can also make deeper connections beyond mitochondria, by looking at how fascia (water-collagen networks) are also linked here from both a bioenergetic/biomechanical perspective.

Basically, the tight muscles/connective tissue in your neck, head, and even all over your body could be giving you clues around your link to hair loss. It's tied to energy flow. Some key patterns/symptoms include:

- Head-forward posture
- Jaw tension/TMJ dysfunction
- Poor diaphragmatic tone or shallow breathing
- Thoracic outlet compression
- Tight suboccipitals

Fascia acts like a network of electrical cables, in which under mechanical tension/strain and/or heat - it transduces the energy into usable electrical energy for our biology to capitalize on. This is one of the mechanisms we use to maintain a near-zero entropy state, consistently.

You need infrared light (42% of sunlight, predominantly IR-A) to supercharge your mitochondria to make large amounts of ATP and H2O (via cytochrome c oxidase) to hydrate fascia, increases mitochondrial melatonin (controls free radicals, autophagy/apoptosis), IR-A light also enhances collagen synthesis, and basically all of IR light (700-3000nm+) allows for the charge separation of water to make it quantum coherent, driving a quasi-free pool of electrons and fast-acting proton tunnelling.

Ultraviolet A (UVA), red, and IR-A also increase nitric oxide production which is connected to blood flow and optimizing stem cell biology (pmc.ncbi.nlm.nih.gov/articles/PMC89…)

TGF-B1 (induced locally by DHT - the fireman) leads to dysregulated collagen formation (fibrotic-like effects) and is linked to mitochondrial dysfunction.

Artificial blue light and nnEMFs (eg., phone, LEDs, screens, Wi-Fi) lead to disruption of all the above by inducing hypoxia, activating collagen-degrading enzymes (e.g., MMPs via excess cortisol), and impairing mitochondrial function/dynamics. This not only has a local effect, but a systemic effect.

Any level of potential dehydration, fascial tension/stiffness, poor posture, or suboptimal mitochondrial output (rise in heteroplasmy, ROS/RNS, biophotons) will reduce the crystalline nature of the fascia - this lowers its semiconductive ability (energy/information) and blocks the flow of DC electrical current (as mapped by Robert O'Becker). You need this current to regenerate stem cells for differentiation/proliferation.

Hair is something you can live without, which is exactly why, as heteroplasmy rises (AKA aging), your body begins to shut off non-essential outputs like hair growth.

In essence, hair loss is protecting you by downregulating local energy, redox, and semiconductor production. It’s a forced downgrade of your biological semiconductive infrastructure, because the system can no longer afford the energetic cost of full operation.

It simplifies electrical circuits and conserves the remaining energy in the face of rising entropy/heteroplasmy.

Same goes for HAIR GREYING - where MELANIN is also degraded, another fundamental semiconductor.

The cherry on top in the modern world, the system has been HIJACKED to not only target energetic issues in the scalp, but every single tissue in your body. Hair loss is just the beginning of worse to come.

https://x.com/jack_schroder_/status/1900741426746687868

I just don't think people understand how complex gut health optimization really is.

It's not as simple as:

"Just fast for 3 days for a reset"
"Avoid gluten and dairy"
"Take BPC-157"
"Take some probiotics"
"Get some sunlight on your abdomen"

You do these things, and it barely moves the needle.

The gastrointestinal system is by far the most complex region of the body - maybe even moreso than the brain.

The rabbit hole of understanding the gut and its complexities is never-ending. Constantly slapped by the Dunning Kruger effect.

You need to consider:

- The potential bacterial, fungal, and parasitic infection - not only that, but they often co-exist. Usually alongside leaky gut barrier and dysregulated motility/digestion.

- The certain substrates that these specific pathogens utilize - understanding that it's not just avoidance of gluten, dairy, FODMAPs, starches/sugars, nickel, etc. - but it ultimately could be a huge combination to initially dampen inflammation. Obviously within reason, but seasonal foods/eating almost goes out the window when one is trying to heal their gut and body. What's important though, is ensuring micronutrient saturation.

- Not only the harmful pathogens at play - but also the state of the whole microbiome, including the beneficial species/strains (eg., most Bifidobacterium, Lactobacillus, but then individual strains like Faecalibacterium prausnitzii, Akkermansia Muciniphila, etc.)

- Supporting the vagus nerve/parasympathetic system and enteric nervous system through specific interventions/tricks around lifestyle, nutrition, and supplementation.

- Optimizing the gut lining - covering all things tied to the relationship between Paneth cells (antimicrobial peptides, gut lining regeneration), intestinal epithelial cells, and the influence they have on the microbiome, and vice versa.

- Supporting mucus production (glucose, butyrate), sIgA (copper, vitamin A, vitaminD), glycocalyx (EZ water, GAGs), and collagen as the first crucial layers to gut lining defense.

- Supporting liver-gallbladder-gut cycles of bile acids and detoxification, not only this, but supporting any organ associated to the gut (eg., kidney, pancreas).

- Ensuring proper sunlight exposure and darkness at night to not only support circadian biology, but also supporting POMC/alpha-MSH/melanin, water/hydration, mitochondrial function, oxygen tensions, vitamin A/D, blood flow, melatonin, collagen, dopamine, serotonin, steroid hormone production, leptin, GABA + glutamate, and much more.

- Beyond above, mitochondrial function, supporting redox/minimizing inflammation, supporting GALT systems, nervous system regulation, and optimizing light/nnEMF environment.

- Multi-purpose supplementation + functional foods (depending on the case): Colostrum/lactoferrin, L-glutamine, mastic gum, magnesium (prioritize topically if poor digestinon), curcumin, ginger, zinc L-carnosine (balanced w/ copper intake), berberine, S. boulardii, PEA, chitosan, modified citrus pectin, taurine, black seed oil, NAC, aged garlic, aloe vera juice, skullcap, slippery elm, electrolytes, seafood, shellfish, organ meats, arugula, coconut oil, pomegranate juice, cacao/dark chocolate, stewed apples, and so on. Peptides if necessary.

The art is combining symptoms, blood work/labs, and crafting nutrition, supplementation, and lifestyle protocols (with adjustments/monitoring, of course) based off deep conversations + constant support with individuals to allow for proper healing and optimization.

Constantly learning everyday around the connections amongst this stuff and how it ties in with other systems. Nevertheless, it's one of the most important ones to optimize. If you want to learn more for yourself and dive deeper: Search key words like "gut", "bile", "infection", etc. into either myself, @GutOptimized , or @Mitopapi's profiles.

Not sure where this was said, but the idea that drinking less water to allow for vasopressin (ADH) to rise in men, allowing for more "masculine" traits around being possessive and territorial, is simply looking at this neurohormone one-dimensionally. Vasopressin is a circadian-based hormone, it follows a diurnal pattern, with levels generally higher during the night and lower during the day. It also gets released under various stressors.

The nuance with vasopressin and its pharmacology (and any neurotransmitter as a matter of fact), is that there are several receptor types -- vasopressin has 3 different receptor sites which act in different tissues (AVPR1A, AVPR1B, AVPR2).

Both ultraviolet & infrared light positively influence your gut.

— UV light altered microbiota diversity, proving light shapes the gut.
— IR light therapy can shift microbial populations.

If man-made lights can do this — imagine what sunlight does to your gut?🤔

Thread🧵 Bosman et al. (2023): Demonstrated that narrow-band UV light exposure can significantly alter gut microbiota diversity and increase vitamin D levels, showing a direct link between light exposure and microbiome modulation.

Hamblin et al. (2019): Reviewed PBM’s impact on the human microbiome, noting its potential in modifying microbial populations and influencing health outcomes.

These are just a couple of the many papers out there reviewing photobiomodulation on gut health.

You think of someone—and then they message you.

You feel emotion out of nowhere—then hear someone close is going through it.

You sense what your partner feels before they speak.

That’s not coincidence, it's quantum entanglement.

And this is how it works: 🧵 Most people think of quantum entanglement as an abstract concept confined to physics.

But what if I told you it’s happening in your body—right now?

And not just in your neurons or DNA, but in your emotions, your instincts, your actions, your so-called random thoughts that end up not being random at all?

Everyone misunderstands hair loss.

They blame androgens (testosterone/DHT), but as you can see in the graph below, that’s just a surface-level scapegoat.

Your body no longer considers hair growth a priority—because your system is under chronic STRESS.

Here's the truth: 🧵 Hair loss is no doubt, one of the most complex issues that occurs in humans, there are so many factors that need to be taken into account & one's situation is simply not the same as another who has hair loss.

Taurine is not just an “energy drink” ingredient.

It’s one of the most powerful yet overlooked molecules in the body—a multi-tool for energy, repair, and longevity.

The modern world makes most people dangerously low in it.

Here’s what it really does (& how to get more): 🧵 Taurine. It doesn’t get turned into protein.

It doesn’t get as much attention as supplements like creatine or magnesium.

But in the shadows, this humble sulfur-containing amino acid plays a huge number of roles across your body—it is very multi-functional.

And you probably need more of it.

Dermatologists make me laugh.

They think melanin is harmful, yet it protects you from sunlight by absorbing it?

But this isn’t just a skin pigment—it’s a bioenergetic molecule found deep within your body that allows you to unlock optimal health & vitality.

Here's how: 🧵 I love talking about melanin—can't you tell?

Melanin is a powerful semiconductor, beyond this it's an endogenous redox modulator, toxin/metal chelator, and participates in non-linear optics within our body.

Who would have thought that something as simple as applying pressure to your body with a lacrosse ball could have the potential to alleviate blockages in energy/information flow (AKA Qi, Prana, or quantum energy), reduce muscle and joint pain, improve overall posture and breathing mechanics, and the most fascinating part—facilitate trauma release.

This is how it works (myofascial release and trauma release): 🧵
If you've ever had a massage, acupuncture, or done myofascial release (MFR) on yourself, you may have experienced an amazing feeling of release afterwards—usually on a biochemical level expressed via endorphins, serotonin, dopamine, endocannabinoids, GABA, and oxytocin neurochemistry being heightened—both acting in the central nervous system and the peripheral nervous system.

One of your most important hormones gets released at midnight every night (no it's not melatonin).

However, most people in the modern world never get the right signal.

This hormone controls appetite/hunger, fat burning pathways, energy homeostasis, thyroid/sex hormones, and more.

Leptin—one of your main circadian hormones—let's have a look at what it does, and how you can optimize it: Alongside melatonin & cortisol, leptin is one of our main circadian hormones that gets released at peak levels around 11:00 PM - 3:00 AM—provided one has their circadian biology dialled in.

It gets released from our white adipose tissue & acts in many other tissues, most importantly in the brain, acting as a conductor of downstream hormone & neurotransmitter pathways.

Sunlight/UV light on your surfaces has huge healing potential & a lack of it is where problems arise.

Show this to your family member, local dermatologist, or a fellow sunscreen/sunglasses maxxer that still isn't convinced.

The relationship between sunlight & our biology goes far BEYOND vitamin D synthesis—it's a symphony of neuroendocrine, immune, & metabolic responses, all working in concert to adapt us to our environment.

Here are some key takeaways about how UV exposure impacts the body in ways you may not expect:
The skin, often overlooked as an active endocrine organ, is equipped with an intricate network of sensors that detect UV & visible light.

These chromophores—melanin precursors, aromatic amino acids, nucleic acids, lipids, peptides, purines, pteridines, etc.—absorb light & initiate cascades of biochemical signals.

Light is information (as well as food, temperature, grounding, etc.), & information determines the fate of biochemistry within you.

Sex isn’t just physical—it’s a quantum event.

It’s an bio-energetic exchange of light, energy, & consciousness.

But who you connect with shifts everything.

Casual sex, masturbation, & love-driven sex hit your biology differently (for better or worse).

Here’s why it matters: Sex is one of the most powerful biological & quantum events that humans can experience.

It serves as a direct interface between matter, energy, & consciousness.

It is a dance between man & woman in the exchange of electrons, protons, & photons—a dynamic, synchronized flow of charge, light, & life force.

It allows for the synergism of vibrational frequencies to become one.

The silent force shaping your life—for better or worse:

Your thoughts.

You might not realize it, but the way you think is literally shaping your reality, emotions, behaviour, & even your overall biochemistry.

Your mind is your greatest tool—here’s how to optimize it: 🧵 This thread will be divided into 2 parts:

The biochemistry & mechanisms behind how your thoughts shape your biology,

& the practical strategies to rewire your mind for optimal health, cognitive function, emotional resilience, & longevity.

If you’re 21 or older, you’ve already lived through over 50% of your life.

This is largely influenced by your biochemistry & how your brain perceives time.

Here’s how it works, & how to tap into that childlike sense of time again: 🧵 The average lifespan for a man in the Western world is approximately 78 years.

This means "middle age" starts closer to 39, not 50.

However, when you account for how our perception of time accelerates as we age (roughly 1/age), the experiential midpoint of life actually occurs around 21 years old.

But this doesn’t take into account how the modern world accelerates time. I believe this is a huge factor.

This concept also applies to our ancestors who, despite shorter lifespans, likely experienced a slower perception of time.

Unlike the modern world, where hyperstimulation & constant distractions amplify our sense of time speeding up, their simpler, more ancestral, more present-focused lives would have stretched their perception of time.

Let’s dive into the mechanisms behind all of this.

Obesity isn’t just “extra fat”—it’s a full-scale renovation of your body’s cellular architecture: the extracellular matrix.

This living network of water, collagen, & proteins gets remodelled in ways that disrupt energy/information flow & signalling.

Result? Chaos. Inflammation. Dysfunction.

Here’s how it all works: 🧵 Whenever one is accumulating fat tissue, it must undergo constant renovation & remodelling within the extracellular matrix (ECM).

The ECM is home to a huge network of water, collagen, glycolipids, glycoproteins, & sugars.

SAUNA EFFECTS ON BIOLOGY—what it does:

· Enhances EZ water networks
· Drives mitochondrial biogenesis & function
· Boosts redox potential
· Lowers all-cause mortality by 40%
· Aids fat loss, detox, & muscle growth

A deep dive into the science & practical use—a HUGE thread: 🧵 There’s a reason hot therapies like sweat lodges, sweat houses, banyas, & saunas have been practiced for thousands of years.

If you’ve ever stepped inside one, you’ll know the feeling you get—relaxed, euphoric, & restored. It’s an intuitive sense of healing that gets reinforced, much like the benefits we experience from other natural stimuli, such as sunlight or social interaction.

Saunas are an incredible tool to utilize for its huge list of health benefits, especially in the modern world—so let’s dig in to the biochemical & biophysical effects:

Sorry, but if your home looks like this after dark—blue light-blocking glasses won’t cut it.

To optimize your circadian biology (which governs EVERYTHING in your body), you must go further than just wearing glasses.

Here's why (+ tips to level up your light environment): 🧵 Most good-quality blue light-blocking glasses will block ~400-550nm, this is excellent as it removes the sharp blue light peaks from tech devices, downlights, LEDs, etc.

On top of blue light, it also removes purple, green, & some yellow light, giving the visuals of a mostly red & orange tinge to your environment.

THE ULTIMATE GUIDE TO MUSCLE GROWTH

Although exercise is important, building muscle goes MUCH deeper—it’s about optimizing your whole system.

Master your training, nutrition, lifestyle, & overall biochemistry to unlock peak results.

Here’s EVERYTHING you need to know: 🧵 This thread will be broken into two parts:

First, we’ll explore the science behind muscle growth in-depth, & the biochemistry/biophysics tied to it.

Then, we’ll cover practical strategies to help you achieve it.

Feel free to skip to the second section if you’re only focused on actionable tips.

Everyone loves talking about hormones, but there’s something that controls ALL of them, affecting:

• mood & behavior
• energy, libido, & appetite
• sleep & stress

It all starts in your hypothalamus—if it’s off, everything else follows.

Here’s how to support/optimize it: 🧵 The hypothalamus is the brain's command center for all hormones—affecting mood, energy, appetite, metabolism, body composition, stress response & more.

When it’s off, so is your health. You need to address it from the top-down, & the hypothalamus is at the top of the hierarchy.

This will be a deep dive into the mechanisms, & how to best optimize it.