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Salmonella admirer - focusing on the African iNTS epidemic, using functional genomics.
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26 Aug 20
African S. Typhimurium ST313 has 23 Lineage 2-specific pseudogenes, discovered by
in 2009, inc ybjZ.
But what is function?
In collab with Jared Honeycutt
, we've discovered that MacB (YbjZ) influences pathogenesis of ST313
Genomes of 285 S. Typhimurium isolates revealed lineage-specific SNPs = macA & macB are pseudogenes
Suggesting that MacAB-TolC efflux pump is functional in S. Typhimurium ST19, but defective in ST313 Lineages 1 & 2
Beautiful expts designed by Jared Honeycutt &
show MacA variant & truncated MacB protein made ST19 sensitive to C18G antimicrobial peptide
& the ST313 macAB SNPs reduced intra-macrophage replication & fitness in murine GI tract
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