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Jay Hinton Profile picture
Jay Hinton
@jay_salsa
Salmonella admirer - focusing on the African iNTS epidemic, using functional genomics.
Aug 26, 2020 • 6 tweets • 7 min read
1/5
African S. Typhimurium ST313 has 23 Lineage 2-specific pseudogenes, discovered by @DrRobKingsley in 2009, inc ybjZ.

But what is function?

In collab with Jared Honeycutt @monack_lab, we've discovered that MacB (YbjZ) influences pathogenesis of ST313

journals.plos.org/plospathogens/… 2/5
Genomes of 285 S. Typhimurium isolates revealed lineage-specific SNPs = macA & macB are pseudogenes

Suggesting that MacAB-TolC efflux pump is functional in S. Typhimurium ST19, but defective in ST313 Lineages 1 & 2