Excited to share our work on subcutaneous administration of hydrophobic, vesicant anticancer drugs via water-soluble polymer prodrugs out in @J_A_C_S Wonderful team effort! @ERC_Research @UnivParisSaclay @CNRS @INC_CNRS @CNRSIdFSud @Pharma_UPSaclay doi.org/10.1021/jacs.2…
🧵1/n 👉 Chemotherapy is almost exclusively administered intravenously (IV) which has serious limitations:
➡️Patient discomfort (central route🩸, catheter failure…)
➡️Frequent hospital stays🏥, trained staff🩺👨‍⚕️needed…
➡️Costly (and cost will 📈 as new cancer cases will 📈)
🧵2/n

🧵 Based on an analogy with AAm/Sty copolymers that exhibit #UCST properties we managed to replace Sty by aromatic ring-containing CKAs (MPDL & BMDO) to obtain degradable, UCST copolymers
✅Synthesis by #RAFT
✅UCST (w/ MDO = no UCST)
✅Degradation in accelerated conditions
1/9

https://twitter.com/julnicolas/status/1529055420559593473

The UCST can be finely tuned by simply varying the amount of CKA in the copolymer. With BMDO, Tcp = 22-55°C, thus covering r.t. and the body temperature, and opening the door to biomedical applications 💊 #hyperthermia 2/9