MELANIN’S ROLE IN IMMUNE SYSTEM AND MS

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Kreutzberg & Kreutzberg explores how peripheral immune cells cross the blood–brain barrier (BBB) to shape CNS immunity, repair, and autoimmunity (e.g., multiple sclerosis, MS).

🐐Let’s start by saying this universal truth → Mitochondria gives cells a tan:
The skin is the dominant “training ground” for T-cells that later patrol the brain, —and melanin density in skin is a key evolutionary switch that explains the global MS gradient (near-zero in equatorial Africa, high in Scandinavia).

🐐 Melanin is a core immunomodulator not just a pigment.
Melanin as an Antimicrobial Shield
“Melanisation of the skin has been recognized as an essential component of skin innate immunity with melanocytes and melanin exerting antimicrobial functions.”

What does this mean?
Skin is the body’s largest immune organ:
👉🏿Melanin (eumelanin granules) physically traps and chemically neutralises bacteria/fungi via:
ROS quenching (super-oxide, H2O2)
👉🏿Metal chelation (Cu2+, Fe3+ needed by pathogens)
Direct bactericidal peptides released from melanosomes
Result: fewer microbial danger signals → milder dendritic-cell activation → less aggressive T-cell priming in skin-draining lymph nodes.

Ref:
Mackintosh (2001) & Breathnach (2014) – melanin kills Candida, Staph, E. coli in vitro; black skin shows lower wound-infection rates.

Melanin Density Predicts MS Risk:
Pale-skinned people have a 32.4 % higher risk of a first demyelinating event and earlier onset… measured by melanin density at sun-protected sites.” (Australian case-control studies)

Figure 3: contrasts two pipelines:
Pale skin→ UV penetrates → dendritic cells release low vitamin D → T-cells up-regulate CXCR6 → aggressively home to CNS grey matter → MS plaques.

Melanin rich skin [Dark skin]→ melanin blocks UV → higher local vitamin D → T-cells stay “calm” → minimal CNS entry.

Melanin density >2.5 % (Black African) → MS prevalence <5/100,000
Melanin density <1.0 % (Nordic) → MS prevalence >200/100,000

Elaborating the Melanin–Immunity Axis (Beyond the Paper):
The authors stop at epidemiology, but the last 3 years of literature flesh out four molecular levers melanin pulls:

Calcium hijacking inside phagosomes:
👉🏿Fungal melanin sequesters Ca2+ → blocks calmodulin → forces macrophages into glycolysis + HIF-1α → 10-fold higher TNF-α/IL-1β (Nature Comm 2020, 2024).

👉🏿M2-macrophage → VEGF → melanogenesis loop
Healing-phase (M2) macrophages secrete VEGF → melanocytes make more melanin → melanin then dials down M1 inflammation (Sci Rep 2022).

👉🏿Melanocyte PRRs & cytokine orchestra:
Melanocytes express TLR1-9, NOD2, RIG-I.
Viral RNA → type-I IFN + CXCL10 → recruit Treg cells (PubMed 2025 review).

👉🏿Furin cleavage blockade:
Melanin binds the pro-protein convertase furin → prevents SARS-CoV-2 spike priming → 40 % lower infection rate in high-melanin cohorts (Transl Med Commun 2020).

Uncle @DrJackKruse ( wife @chantaldillon10 ) is the only doctor who ever mentioned MELANIN Rx for modern men and women using Daylight spectrum, cold thermogenesis, quantum biology

Daily practical implications
👇🏿🔆🧌
MS prevention: Never Miss a sunrise, omega 3 fatty fish maxxing
680 nm red-light devices (bypasses melanin) to deliver vitamin-D equivalents to pale skin.
UVA light skin exposure activates POMC = more melanin → diabetic ulcers (ROS-scavenging + antimicrobial).
COVID/flu: nasal melanin droplets [Just get daylight instead and maintain darker nights] proposed in South Africa 2023—early trials show 68 % reduction in viral load.

The paper uses melanin only as a geographic bookmark for MS risk, but the molecule itself is a Swiss-army knife of innate immunity: UV filter, ROS sponge, metal trap, Ca2+ sink, cytokine rheostat, and furin inhibitor.
Higher constitutive melanin = fewer hyper-reactive T-cells escaping to the brain = near-zero autoimmune CNS disease in equatorial populations.

END 🧵

Ah look 👀!! The man said obesity like all other mitochondria diseases begins in the eyes. Dopamine and Melatonin is produced in the eyes in IR-A and UVA light. So when melatonin is ruined in the eyes so follows dopamine. Melatonin maintains the mitochondria Ferrari.

You have to insert the sun in yours eyes. Eyes and skin in the quantum dance of life
Part 1 instagram.com/p/DIdYe7zImfE/…