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Co-director, Center for Inherited Oncogenesis and AD for #Postdoc Affairs @UTHealthSA #ovariancancer #endometriosis #genetics #epigenetics #singlecell
Nov 12, 2019 10 tweets 8 min read
Our new paper is on biorxiv! "Predicting master transcription factors from pan-cancer expression data" biorxiv.org/content/10.110…. We set out to find master TFs in ovarian cancer, and went on quite a journey... A few highlights in the thread 1/ Prioritizing candidate MTFs without ChIP-seq data is tough, so we developed a gene expression-based approach which we loving called the Cancer Core Transcription factor Specificity (CaCTS) algorithm 🌵. (We then decorated the lab in cactuses) /2