Happy to share “The expanding family of Tfr cells”, a Focus on @SciImmunology (@lgraca, @saum_kmr & @jotraceyja24) about a @nromberg_ ’s paper. Follow this thread for a summary of Tfr diversity (and @nromberg_'s work). science.org/doi/10.1126/sc… @IMMolecular @medicina_lisboa The first Tfr cells described, derived from Foxp3+ Treg cells, are the most abundant, autoreactive (TCR similar to Treg's), and they come in two flavors: CD25+, and the most mature CD25- (to escape IL-2 inhibition). Check this review from our group:
doi.org/10.1111/imr.12…

Happy to share our 1st publication of 2023! Hybrid immunity (protection against Omicron BA.5 infection acquired by vaccination + Omicron BA.1/BA.2 infection) is stable over 8 months. Data from the 🇵🇹registry.🧵1/12
thelancet.com/journals/lanin…
@IMMolecular @lgraca @TheLancetInfDis We previously showed that BA.1/BA.2 infection in a highly vaccinated population (Portugal) provides substantial protection against subsequent omicron BA.5 infection: nejm.org/doi/full/10.10… Similar results reported in Denmark and Qatar. What about the waning of protection? 2/12

Proud to present BA.5-infection risk drops after BA.1/BA.2 infection – data from the national Portuguese registry, one of the countries first hit with BA.5. Important, as adapted vaccines in development are BA.1-based. Follow the twitorial! 1/9 @lgraca medrxiv.org/content/10.110… First, we used the SARS-CoV-2 genetic diversity surveillance data (great work from @irj_pt and J.P. Gomes) to define periods where each variant was dominant (>90% of national sample isolates). 2/9 #COVID19PT #DGS #INSA #InstitutoRicardoJorge