Excited to share our new pre-print on immune responses during mild SARS-CoV-2 breakthrough infection! We studied the kinetics of antigen-specific B cells, CD4 and CD8 T cells, and antibodies to understand how each response was activated during infection.

biorxiv.org/content/10.110… We know that mRNA vaccines generate immune memory, but protection against infection gradually wanes after vaccination. Nonetheless, if infection occurs, vaccinated individuals tend to have less severe disease, likely thanks to immune memory.

I'm happy to see our study on T cell responses to SARS-CoV-2 mRNA vaccines is out in @ImmunityCP! This was a great team effort with @divijmathew, @s_apostolidis, @rishirajgoel, @Bad2theBeaker, and of course @EJohnWherry.
Check out the full text here: cell.com/immunity/fullt… Here are the key findings:
- CD4 and CD8 T cells are activated by the vaccines
- The universal CD4 response to the first dose (Th1 and Tfh) may be critical to overall immunity by amplifying responses to the second dose
- Two doses for SARS-CoV-2 naive, one dose for recovered

Our study on T cell responses to SARS-CoV-2 mRNA vaccines is up!

Are T cells primed by the vaccines?
Do they have features of long-lived memory cells?
Do they contribute to the overall immune response?

A thread on the key findings below 🧵

biorxiv.org/content/10.110… First of all and most importantly, this was a great team effort alongside co-first authors @divijmathew, @rishirajgoel, and @s_apostolidis. It is a thrill to work with such brilliant and dedicated scientists every day.