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Mark Robinson @markrobinsonca@genomic.social Profile picture
Mark Robinson @markrobinsonca@genomic.social
@markrobinsonca
statistical bioinformatics; swissified canadian; #methodsmatter #rstats; open science advocate; grumpy towards prestige worshippers, excessive admin and bros.
Aug 31, 2021 • 9 tweets • 3 min read
Ever been frustrated doing QC of your single cell (RNA-seq) data? .. especially when you expect to have rare celltypes?

Check out SampleQC ..
bit.ly/3DpDTLg

(n.b.: thread drafted by @willmacnair) This work was motivated by trying to do QC on a large, challenging dataset, and finding that existing methods were either throwing away cells we wanted, or not removing anything at all.
Jul 26, 2019 • 10 tweets • 4 min read
So, this preprint came out today ..
bit.ly/2K4jKzK
Let me (not so) briefly explain a few things .. first, let me say it's been a super fun project and a huge tour-de-force from our very talented @CrowellHL .. and lucky for us, we benefit from the ever-present wisdom of @CSoneson, some great insights from Pierre-Luc Germain along the way and great collaborators at Roche.
Jan 10, 2018 • 7 tweets • 3 min read
Somewhat bizarre essay out of @Stanford: goo.gl/BPgaeZ
So .. clustering 'high' dimensional cytometry data. They claim to "show directly how the curse of dimensionality leads to invalid conclusions" .. .. but what they actually show is that methods to estimate the the *number* of clusters have problems (Yvan Saeys et al. rightly point this out in their reply: goo.gl/HS7XZY) .. and this is already well-known (e.g., @lmwebr's paper: goo.gl/ktdXXy) ..