Can we talk for a minute about the randomized controlled trial (RCT)?

No one can refute that RCTs are one of the most important innovations in the past 50 years. 1/23 Although the famous RCTs are known for overturning existing dogma (CAST study, intensive glucose control in diabetes, hormone replacement therapy…), less famous RCTs have led to thousands of treatments applied daily (each linked to a specific RCT demonstrating benefit) 2/23