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Martin Sip Profile picture
Martin Sip
@martinsipx
Looking into longevity and nutrition (low-carb low-omega-6 fats #lcl6). Self-directed education. Full time father.
Jun 19, 2021 • 9 tweets • 3 min read
Dietary PUFA are oxidized preferentially in postprandial period.

"Polyunsaturated:saturated ratio of diet fat influences energy substrate utilization in the human"

pubmed.ncbi.nlm.nih.gov/3123874

#lcl6

1/9 Image Diet of 45-40-15%en fat-carbs-protein for 7 days + crossover of two PUFA:SFA ratios (P:S):
- low P:S = 0.24, PUFA 5%en
- high P:S = 1.65, PUFA 17%en

2/9
Mar 26, 2021 • 11 tweets • 2 min read
Breakdown of extracellular matrix (ECM) as one of possible causative factor in cancer!

Never heard much about ECM pathology before. Fascinating.

1/11 "Matrix within cells, the cytoskeleton, and that which surrounds cells, the extracellular matrix (ECM), are connected to one another through a number of receptors including those in primary cilia, serving as an important chemical and physical signaling system."

2/11
Feb 8, 2021 • 15 tweets • 5 min read
Susceptibility to sunburns on high n-6 diets:

"UVB and H2O2 induced G2A expression and caused oxidation of linoleate to produce 9-HODE in HaCaT cells. [This] suggests that 9-HODE-G2A signaling plays proinflammatory roles in skin under oxidative conditions." Image G2A Plays Proinflammatory Roles in Human Keratinocytes under Oxidative Stress as a Receptor for 9-Hydroxyoctadecadienoic Acid

sciencedirect.com/science/articl…

#lcl6