In-depth analysis of research on myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).
4 subscribers
2) In our view, the clearest signals point to genes such as CA10, SHISA6, SOX6, LRRC7, and DCC, which are involved in neuronal development and communication in the brain.
2) DecodeME is by far the biggest study on ME/CFS ever done. It may not have caused a big breakthrough, but it adds an important piece to understanding the puzzle of ME/CFS.
2) In brief: BPS proponents think there is no objectionable pathology in ME/CFS, so they see the disorder as mainly caused by the belief one is ill and the inappropriate resting behavior that follows (sleeping too much, exercising too little, focusing on symptoms, etc.).
2) He thinks there is something in ME/CFS patients that keeps the sickness response alive. And to study the illness and make it visible, one has to put the cells under different types of stress.
2) She claimed that immunoadsorption led to an improvement in about 75% of treated ME/CFS patients but that this improvement is unfortunately not sustained. It's not a curative treatment. 
2) This study had much less participants than DecodeME: only 1815 cases and 5008 controls that came from 3 different cohorts and were added together using a meta-analysis approach.
2) Some background: in a previous study these researchers found that ME/CFS patients hade more antibody binding to multiple pieces of protein derived from the Epstein-Barr Virus. 
2) Metformin is mostly known as a drug for type 2 diabetes as it lowers sugar levels in the blood. 
@davidtuller1 2) Lipkin explained that in the 1990s, his team looked at whether Bornavirus might be the cause of ME/CFS. They found no evidence of that, but they did see immune activation (nonspecific polyclonal B-cell activation) in a majority of patients.
2) Funding goes to Dr Fatima Labeed (United Arab Emirates University), who authored the initial research, and Dr Jacqueline Cliff, who will host the work in her laboratory at Brunel University of London.
2) Natural Killer (NK) cells are a type of immune cell and have been implicated in ME/CFS for more than 30 years. The most consistent finding is reduced cytotoxicity of NK cells; their ability to destroy other cells.
2) The authors used O2 pathway analysis, which breaks down oxygen transport into independent parameters. In ME/CFS and Long Covid patients, the problem seems to lie in the DM parameter, which stands for muscle diffusion capacity (moving oxygen from blood to muscle cells).
2) To trigger post-exertional malaise (PEM), the authors didn't use an exercise test but an inflatable cuff that gives pulsatile compressions to the patient's forearm. 
2) There were a lot more ME/CFS studies that measured CBF than we expected: 26 on ME/CFS alone and 11 in both ME/CFS and OI. 
2) OLFM4 is expressed in gut epithelial cells and is stored in the granules of neutrophils, the most common type of white blood cells.
2) This comes from the research group of Jeroen Den Dunnen, whose preprint showed that transfer of antibodies (IgG) from Long COVID patients induces symptoms in mice.
2) They zoomed in on the muscle capillaries, the tiny blood vessels that are so small that red blood cells need to move through them one by one.
2) Previous studies suggested that red blood cells change their shape more easily when oxygen is low. That allows them to move faster through small blood vessels (capillaries) and deliver oxygen where it is needed.
2) The experiment used multiple fatigue measures during the task: 
2) A short recap of the evidence:
2) Their experiments were inspired by two studies finding ME/CFS and long COVID-like symptoms in mice after transferring IgG from patients.