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Maru Profile picture
Maru
@mellases
PhD | Biomoléculas, metaloproteínas, electron transfer ⚡👩‍🔬 | Feminista 💚 | Futbolista ⚽️ | Arg 🇦🇷 | She/Her |
Sep 7, 2020 • 7 tweets • 4 min read
Hello @LatinXChem! Today I want to share my latest work about the mechanisms of assembly of CuA Site by mitochondrial metallochaperones. Done at @IBR_CONICET and @VilaLab, in collaboration with @soy_MAC and @labriataphd. #LatinXChem #LatinXChemBio #BIO045 (1/5) Image We found that A. thaliana Sco1 binds both Cu(I) and Cu(II) with high affinity. We analyzed both copper sites by spectroscopic methods, XRay crystallograpy and DFT, confirming that Cu(I) tri-coordinated (2SCys-NeHis) and Cu(II) tetra-coordinated (2SCys-NeHis-H2O) (2/5) Image