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Michael Fischbach Profile picture
Michael Fischbach
@mfgrp
Liu (Liao) Family Professor of Bioengineering, ChEM-H @Stanford.
Dec 11, 2024 • 55 tweets • 16 min read
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @DjenetBousbaine led the charge... @Nature 1/55 Image ...w/ help from @kdbauman_ and @plalgudi11 (link below). This was a collaboration with Inta Gribonika and @BelkaidLab, who have an accompanying manuscript that was co-published with ours. It's a wild story. 2/55
nature.com/articles/s4158…
Apr 11, 2024 • 53 tweets • 11 min read
How to pick a problem. Today in @CellCellPress. 1/53
cell.com/cell/fulltext/… Your career = a finite number of weeks. Most would agree that time is precious & should be used for maximum impact, but acknowledging this and practicing it are two different things. Especially important when choosing a problem, which can impact time allocation for years. 2/53 Image
Aug 16, 2023 • 40 tweets • 13 min read
Today we report a detailed map of interactions between the immune system and the gut microbiome. @MicrobiomeTcell led the charge w/ help from Aishan Zhao and Kat Atabakhsh. @Nature 1/40
nature.com/articles/s4158… Two lines of prior work were essential here. First, Dan Littman, @BelkaidLab, Fiona Powrie, Greg Barton & others showed that certain colonists induce a potent T cell response. 2/40 Image
Apr 13, 2023 • 26 tweets • 11 min read
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent immune response against a distant tumor. @yerinchen led the charge w/ help from @DjenetBousbaine, @VeinbachsA, @BelkaidLab. @ScienceMagazine 1/26
science.org/doi/10.1126/sc… In prior work, Littman, @BelkaidLab & others showed that certain colonists induce a potent T cell response w/ 3 attributes: T cell "flavor" is determined by the microbe, T cells are antigen-specific, and this happens preemptively: w/o infection, across an intact barrier. 2/26
Sep 6, 2022 • 22 tweets • 9 min read
Today we report a new model system for the gut microbiome: hCom2, a defined community of 119 strains. @AliceCheng107 led the charge, with major contributions from Po-Yi Ho, @DrChilennial, and @SunitJain. Co-led by my longtime collaborator KC Huang. 1/22
cell.com/cell/fulltext/… Two motivating factors. First, we were intrigued by experiments in which a (complete, undefined) fecal sample was transplanted human->mouse & a phenotype came along for the ride (e.g. response to anti-PD1). Fascinating but hard to figure out which strains/genes are involved. 2/22
Nov 9, 2020 • 6 tweets • 2 min read
We knew a pandemic was coming. If we had prepared in advance we could have saved millions of lives & trillions of $. The ROI would have been stunning.

Now that logic is back in the building, 4 other problems we should invest in before they become crises:
cbsnews.com/news/coronavir… 1) US R&D competitiveness
Historically, the US has led the world by leaps and bounds in innovation. Underinvestment and illogical immigration policies have caused us to lose ground. We're learning in real time of the extraordinary impact that academic research + tech can have...