Share this page!

Enter URL or ID to Unroll

You can paste full URL like: https://x.com/threadreaderapp/status/1644127596119195649
or just the ID like: 1644127596119195649

How to get URL link on X (Twitter) App

  1. On the Twitter thread, click on or icon on the bottom
  2. Click again on or Share Via icon
  3. Click on Copy Link to Tweet
  4. Paste it above and click "Unroll Thread"!
  5. More info at Twitter Help
Michael Gandal Profile picture
Michael Gandal
@mikejg84
Neuroscientist and psychiatrist using systems-level genomic approaches to understand autism and schizophrenia. Assistant professor, UCLA-Semel Institute
Mar 5, 2020 • 12 tweets • 5 min read
Very excited to share the 1st (!?) preprint from @GandalLabUCLA & super talented MSTP student Minsoo Kim & excellent team: "Network signature of complement component 4 variation in the human brain identifies convergent molecular risk for schizophrenia" biorxiv.org/content/10.110… Previous work from @s_mccarroll & others showed that increased C4A copy number --> incr expression --> incr SCZ risk, (partially) explaining the largest EUR @PGCgenetics GWAS hit in MHC region ... implicating complement signaling as ?new mechanism for SCZ nature.com/articles/natur…