Statistical Geneticist at Genomics plc, using genetics to unlock precision health
Apr 6, 2021 • 9 tweets • 4 min read
1/9 Hot on the heels of our CAD paper (ahajournals.org/doi/10.1161/CI…) comes our clinical validation across multiple ethnicities and ancestries of a new integrated risk tool for atherosclerotic cardiovascular disease (ASCVD) (shiny post-proof format: ajconline.org/article/S0002-…).
2/9 ASCVD includes both coronary artery disease (CAD) and ischaemic stroke (IS). We meta-analysed 10 GWAS datasets across multiple traits, ethnicities and ancestries to derive our polygenic risk score (PRS) for ASCVD.