1/ Yesterday on stage at Wired Health in Boston, I did something I’ve never done before: I used a radical new medical device live on myself—while speaking. No hospital. No implants. No hole drilled in my skull. Just a lightweight headset, registered to my head using nothing more than a smartphone camera.

With the flick of a switch, I stimulated a cluster of neurons in my anterior cingulate cortex—two inches behind my forehead—while continuing to walk and talk. I could feel the effect: calm, focused, and pain-free.

This wasn’t magic. It’s physics. 2/ The device uses focused ultrasound—but not the expensive, room-sized machines that burn holes in deep tissue to destroy tumors. Ours is small, low-intensity, and radically affordable. It uses sound intensities lower than those used on pregnant women and their fetuses for decades.

Here’s the breakthrough: many types of cells have something akin to a resonant frequency. Just as an opera singer can shatter a wine glass by singing the right note without disturbing anything else in the room, our system can vibrate specific cells at their frequency—neurons, cancer cells, stem cells, even pathogens—while leaving everything else untouched.

Yesterday, I was pinging neurons. But in clinical trials, we’ve gone much further.