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Nael Profile picture
Nael
@naelnadif
Neurobiologist studying the synaptic basis of neuron network dysfunction in brain disorders, chromatin remodelling, stem cell derived neuronal models
May 11, 2021 • 7 tweets • 2 min read
Proud to present our new work: Cadherin-13 is a critical regulator of GABAergic modulation in human stem-cell-derived neuronal networks, spearheaded by talented grad student @brittmossink
nature.com/articles/s4138… We established a robust method to generate a homogenous population of SST and PV expressing GABAergic neurons (iGABA) in vitro, and co-cultured these with glutamatergic neurons at defined E/I ratios on micro-electrode arrays.
May 7, 2020 • 4 tweets • 2 min read
Excited to present a new preprint on how to model E/I balance using #ipsc derived neuronal models. Great work by @brittmossink and nice collaboration with @SchubiNeuro

biorxiv.org/content/10.110… We describe a new and easy to implement protocol to efficiently generate SST+ and PV+-GABAergic neurons from human iPSCs.