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Pooja Navale MD Profile picture
Pooja Navale MD
@navale_pooja
@CooperHealthNJ Formerly @wusm_pathology Past GI/Liver fellow @bidmcpath, chief resident @MountSinai_Path. Proud alumni of @Tatamemorial. T/RTs≠ medical advise
Aug 7, 2020 • 4 tweets • 2 min read
1/4 Gastric Carcinomas with lymphoid stroma
A.k.a lymphoepithelioma like carcinoma/medullary carcinoma
This case was EBV associated and MMR proficient.

Those gastric cancers with lymphoid stroma that are EBV+ are most likely to be mutually exclusive to the MMR deficient ones ImageImage 2/4 The TCGA (The Cancer Genome Atlas) has proposed to classify gastric cancers as-
- EBV-positive
- Microsatellite-instable
- Genomically stable
- Chromosomally Unstable

These cancers can be classified into one of these categories due to the unique exclusivity to EBV & MMR Image
Jul 16, 2020 • 9 tweets • 3 min read
1/9
 Acetaminophen toxicity: A leading cause for liver transplantation in the US and a cause for almost 1/2 cases of acute liver failure.

ncbi.nlm.nih.gov/pmc/articles/P… 2/
 Although toxic dose are usually>150 mg/kg, this could happen in pts taking safe doses- possibly due to aberrancies at the cellular levels.
The FDA recomdtn- reduce max daily dose to 3250 mg, encourage manufacturers to reduce the amount to 325 mg/dose
archivesofpathology.org/doi/pdf/10.585…