In ICU while managing critically ill patients with AKI and -
🔅Septic shock with multiple pressors
🔅Acute liver failure
🔅Cardiogenic shock
🔅Cerebral edema
we all have used the CRRT machines.

Ever wondered how their use started🤔 ???

📍Let's go back to the history of CRRT

🌟The early attempts of continuous hemofiltration were carried out in animals and humans in 1977-78

🌟LW Anderson reported its use in 2 anephric sheeps for 48 and 72 hours

pubmed.ncbi.nlm.nih.gov/715997/

📢 Tweetorial on sepsis -endotoxin- cytokine cascade

👉Pathogen invasion in body

👉Pathogen expresses certain molecular patterns or
endotoxins called pathogen-associated molecular patterns (PAMPs)

👉
PAMPs are recognized by toll-like receptors expressed by
neutrophils 👉 Activation of innate immunity and leukocytes

👉Release of cytokines - pro +
anti-inflammatory(interleukins 1, 6, 8, 10 &
tumor necrosis factor)

👉 Dysregulated host
response to infection - organ failures

👉 Immunoparalysis, reinfection,
hospital-acquired infections