A TWEETORIAL on our new CRISPR-sciATAC preprint. Our lab has been working on combining pooled CRISPR screens with single-cell chromatin accessibility for nearly 4 years so very happy to see this work finally out there in the world. biorxiv.org/content/10.110…
The work was led by 2 talented postdocs in our lab (@noaliscovitch and @antonino_nyc) with support from many other folks in our lab and in @NYGCTech lab. Extra shout-out to @noaliscovitch for getting the manuscript over the final hump in what has been a challenging year.
Oct 24, 2020 • 38 tweets • 18 min read
As promised, here’s an overview of our study to find host factors required for SARS-CoV-2 infection in human cells. We use a genome-wide CRISPR screen to identify genes (& key mechanisms) that might be therapeutically targetable to prevent viral infection.
Here’s a link to the manuscript (open access): cell.com/cell/fulltext/…
Jun 16, 2020 • 25 tweets • 8 min read
Happy to share our new preprint characterizing a recent mutation in SARS-CoV-2 Spike protein (D614G) and its potential functional impact on the ability of the virus to transduce human cells.
