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2/8) For context, Lp(a) is a cardiovascular boogeyman. Unlike LDL, its unique apolipoprotein(a) tail makes it "sticky," more likely to promote blood clotting, and more atherogenic on a per-particle basis.
2/6) Cancer is a master hijacker. In this case, it co-opts the liver. When the liver gets fructose, it turns it into molecules that cancer cells repurpose into specific phosphatidylcholines—key building blocks for cell membranes.
(2/8) When I first opened this paper, I was struck by a simple thought: we socially accept exhaustion but demonize drunkenness.
2/7) Today’s letter is an overdue ~3000-word essay on:
2/8) Study 1: Skews the Truth with “Scores”
2/4) Honestly, the “why” is simple can be summed up in a words: ignorance.
2/8) Researchers compared patients with coronary artery disease (CAD) to healthy controls and found a stark deficiency.
2/8) First, some background. Metabolic dysfunction-associated Steatohepatitis (MASH)—fatty liver—is a serious risk, worsening cardiovascular health and increasing cancer risk. One dietary driver can be fructose, which uniquely enhances de novo lipogenesis: the synthesis of new fat in the liver.
2/5) The researchers in this study noted that the statin therapy caused a 23% reduction in the rate constant of muscle recovery. To quote the authors, this “indicates a decrease in muscle oxidative capacity.”
2/8) When I first read the paper, I noticed something odd.
2/8) First, a promise: There are many ways I could respond to the present moment — but I’m going to try to choose compassion and understanding. By that I mean I’m not going to point fingers or make fun. This moment calls for less fighting, less politics, and more humility.
2/7) The first paper of a triad that gave me the goosebumps was published in Cell Metabolism and found, now paraphrasing: Fat cells and immune cells employ intercellular mitochondria transfer as a mechanism of crosstalk that regulates metabolic homeostasis and is impaired in obesity.”
2/8) Let me start with an analogy: Imagine if I told you that I could instantly communicate with a friend on the other side of the world. You wouldn’t be shocked—you know I have access to email and a phone. But if I clarified, “No, I’ve invented telepathy,” and could somehow prove it to you, is it fair to say you’d be impressed? That’s analogous to distinction we’re dealing with here: an entirely new and direct line of communication between the brain and liver to influence blood sugar.
2/8) The most common form of diabetes — Type 2, often associated with obesity and adult onset — isn’t one disease. It’s actually four different underlying pathologies, showing up in different proportions in different people.
2/7) First, some human context: depression and obesity are highly 'co-morbid'—meaning they often occur together.
2/8) The first three minutes of the clip are devoted to lung cancer, where Peter uses the Socratic method with Andrew to examine the causal relationship between smoking and lung cancer. He ultimately lands on the point:
2/4) But let’s ‘warm-up’ with an intellectually light fact that I bet you didn’t know: Exercise remains the only known physiological stimulus that promotes the generation of new heart muscle cells.
2/10) At a High Level: My Stance on Seed Oils
2/9) In the first experiment, researchers enrolled 30 patients who were starting atorvastatin (20 mg) and 10 control patients who weren’t taking statins. They followed both groups for 16 weeks.
2/9) Now, the pushback we received on this emphasized novel finding (“Plaque Predicts Plaque Progression, but ApoB does Not”) is perhaps one of the silliest arguments I’ve observed in the metabolic health space.
2/9) One specific oxylipin that’s gaining attention is 12,13-diHOME, a derivative of the Omega-6 fat linoleic acid.