PhD @UniofOxford, MD student @Harvard. Metabolic health enthusiast. #LMHR #LEM researcher. Opinions are my own, but data are data. “Stay Curious” 🤓
10 subscribed
Jun 28 • 5 tweets • 4 min read
🧵1/5): Artificial Sweeteners are Sold Simply as “Sweet without the Calories.”
🤔But while your tongue may get confused, your “Gut Sense” is harder to deceive!
Brilliant work from Diego Bohorquez featured on @hubermanlab shows HOW your body Outsmarts Sweet!
In this thread (please watch vids!), I will walk you through data from a landmark paper that I found awesome – truly, a moment when I say back and went “WOW, our bodies are AMAZING!”
At the end, find the link to the @hubermanlab episode, paper, and FULL VIDEO (11.5 min) breakdown.
cc @R_Mohr @scicommedia @gutbrains
2/5) In this study, the researchers identify “neuropod cells,” which are gastrointestinal cells with nerve-like properties that can sense sweet in the intestines with specific receptors (we will get to what these are in a moment), and then transmit the signal to the brain via the Vagus nerve. (👇jump to 0:56 if you're impatient, like me)
Jun 25 • 9 tweets • 8 min read
1/9) 7 Facts About Muscle & Protein 💪
EVERYONE WILL LEARN, even @drgabriellelyon
This thread is going to ‘wade in,’ drawing inspiration from @hubermanlab w/ @drgabriellelyon + extra information, including NEW 2024 data
🚶♂️The First 3 Will be your Warmup
🏋️♀️Then the Main Set
If you genuinely learn nothing, I’ll buy you a Wagyu Steak.
If you learn at least 3 things, consider a RT of the thread or your most ‘mind-blown’ learning
2/9) #1) We Don’t Know How Much Muscle is Optimal.
At the beginning of the podcast @drgabriellelyon points out a simple but important truth: we don’t know the ideal amount of muscle for a given individual.
Certainly, there’s heterogeneity, but how do we quantify “optimal?”
Optimal for longevity (more on that in #5) Performance? What Type and What Distribution, and how do these impact the endocrine functions of muscles?
There are many unanswered questions with respect to “Muscle-Centric Medicine,” which – I think – makes the field EXCITING!
P.S. Random fact about me, and if you wanted to see what I looked like at 13... and yet I've never been able to bump my BMI above ~22 at max... little boi. Maybe @drgabriellelyon can help, lol:
Anorexia is a devastating condition that increases risk of death >5X and is associated w/ high rates of relapse
There is desperate need for more effective treatment options
Mar 22, 2023 • 6 tweets • 5 min read
1/ NEW RCT shows that Fat-Sugar mix
👉 Alters reward circuits in human brain
👉⬇️ preference for lower fat-sugar food and ⬆️ response to milkshake
👉These changes were independent of changes in body weight or metabolic health
... A thread🧵 cell.com/action/showPdf…2/ In this study, normal-weight participants were exposed to EITHER a high-fat/high-sugar snack OR a low-fat/low-sugar snack for 8 weeks in addition to their regular diet. The snacks were to be consumed 2x per day and were isocaloric.
Mar 11, 2023 • 13 tweets • 5 min read
1/ As time has passed and positions have evolved, I’d like to do another thread 🧵 on Satiety Per Calorie (SPC) covering:
👉 And to get at sense of prevailing opinions (Poll!) 2/ First, I’d like to say I’m not against SPC as a HEURISTIC and ABSTRACT concept
Reflecting on what food nourishes and satisfies you is a good exercise, in line with mindful eating. That’s the utility!
Feb 6, 2023 • 10 tweets • 3 min read
🚨Carbohydrate insulin model “dead,” OR is it misunderstood again? 🤥
1/ Doctor Tweeted “that the carbohydrate-insulin theory is completely dead” ☠️⚰️
I recently watch the interview with that doctor, and it was surprising the degree to which s/he got the facts wrong…
2/ The CIM does posit that a high glycemic load diet drives high insulin to glucagon ratio state… as a result energy available in the bloodstream is driven downwards in the late postprandial phase leading to “hormonal, hunger” & overeating…
Feb 4, 2023 • 10 tweets • 4 min read
1/ How to poo 💩! Was listening to the new @hubermanlab with @DrGottfried this AM (at 3:37) on hormones and #constipation & was inspired to do a little thread on my top #6 tips for dealing with constipation ... hopefully this thread helps at least 1 silent sufferer
2/ This is a topic I'm interested in is bc as someone with a hx of proctitis + cecal patch (form of ulcerative colitis strongly linked to constipation), it's something I've struggled w/ at times. It's not fun & a far more prevalent problem than people realize 4 obvious reasons
Feb 3, 2023 • 4 tweets • 2 min read
1/4) “Satiety score” score suggest macadamia nuts are more likely to promote weight gain and prevent weight loss than cheesecake?! (higher = more satiety) 🧐
Macadamia = 17
Cheesecake = 19
Battered fried shrimp = 35
Apple juice = 32
Fried zucchini fritters 27
#satiety
2/4) First, lest address the science. Do macadamia nuts cause weight gain?
In a 4 week interventional trial in which people were instructed to eat 40-90 grams of macadamia there was actually a net weight loss.
1/ It seems the new trend is talking about food "satiety" scores
Superficially the approach makes sense… prioritize foods that’ll keep your full and thus you will lose weight. Sensible, right?
Maybe, or maybe not...
2/ 1st, satiety is an abstract concept
The best one can do is try to operationalize by creating scores based on other variables
@DietDoctor does this
[combines] "factors that make a food more satisfying: protein percentage, energy density, fiber content, and a hedonic factor."
Jan 28, 2023 • 5 tweets • 4 min read
1/4)🚨 WOW! SOO COOL!
NEW DATA in @CellCellPress show that light can directly alter human glucose tolerance via a light-eye-brain-brown fat axis 🧠
5 min video:
ht/ @hubermanlab
2/4) Using 🐁 model researchers show light impairs brown fat thermogenesis and glucose tolerance directly via axis composed of:
I) photo-sensitive retinal ganglion cells
II) supraoptic nucleus
III) paraventricular nucleus
IV) nucleus solitary tract
V) rostal raphe nucleus
Jan 22, 2023 • 6 tweets • 3 min read
1/6) This TW screenshot has received a lot of traction
Personally, I read it as "ketosis itself doesn't enhance weight loss, as compared to carbohydrate restriction without ketones >0.5mM."
Nevertheless, I think this is an interesting topic. So... THREAD! @DrEenfeldt
2/6) First, consider weight loss. RCT data show that carbohydrate restriction can increase total energy expenditure in a dose-response manner
Thus, ketogenic - be virtue of being very low carb - may have an edge in terms of energy expenditure
1) As you may have heard, the FDA has approved the weight loss drug semaglutide (a GLP-1 agonist) for kids 12 and older with #obesity
Good? Bad? I wanted to do a thread 🧵on the STEP TEENS data with some thoughts...
PLZ READ IN FULL 2) Semaglutide Treatment Effect in People (STEP) with obesity TEENS trial was a double-blind RCT that lasted 68 weeks & included kids 12-18 years. 180 completed the trial
But instead, I CHALLENGE YOU 🫵 to put aside emotions & watch 1 of these videos
11 m:
45 m:
1/ NOW for 🧵 on 5 MYTHS about eating Bugs!
A DISCLAIMER
I am NOT trying to take your meat
I am NOT saying meat is unhealthy
I am NOT trying to force you to eat bugs
I am NOT trying to force you to eat bugs
I am NOT trying to force you to eat bugs
I AM asking you to set aside emotion and have an open mind
Begin...
Dec 29, 2022 • 9 tweets • 4 min read
🚨Fascinating NEW peer-reviewed report provides transparency on the "Corporate Capture” of the Academy of Nutrition and Dietetics
👉 Undisclosed conflicts
👉 Bias in public health policy
👉 Money > Health
🧵Thread + Review & Reaction video (5m): 2/ Academy of Nutrition & Dietetics (AND) comprises largest US organization of nutrition professionals: >100,000 dietitians/students
Group goal: “accelerate improvements in global health and well-being through food and nutrition”
AND = authority helping set food policies
Dec 23, 2022 • 6 tweets • 3 min read
#Vegan🌱#keto (low sat fat, 0 cholesterol)
vs.
Meat and Egg heavy diet + 120g net carbs
N=1 Crossover experiment
Surprisingly, LDL >300 mg/dL on vegan keto and ~100 mg/dL on meat and egg plus carb diet 🤯
👉 If this doesn't make you curious, I don't get you 2/ This contradicts the explanation that sat fat is the primary driver of ⬆️ LDL on low-carb
While it may represent an outlier case (& sat fat may primarily drive⬆️LDL in others), that these lipid results can present in anyone requires an explanation beyond conventional wisdom
Dec 21, 2022 • 7 tweets • 3 min read
1/7)🤯 New study in PNAS shows low-doses of sweetener aspartame can produce anxiety behavior 🧠in mice that's TRANSMITTED to their children and grandchildren 👦👶
2/7) The first experiment the team performed in this study was to expose male & female mice to normal drinking water or water with 0.015-0.03% aspartame
Notably this dose is only 7/8-15% the FDA recommended max dose for human intake, and the equivalent of 2-4 diet sodas per day
Dec 20, 2022 • 11 tweets • 3 min read
Thread🧵on Seed Oils that will please Nobody😲
1/10) First, why this thread?
Because I've seen seed oils rise quickly as a perceived villain within (and outside) the low-carb community as a presumed critical cause of metabolic dysfunction
Is this the case? ...
2/10) Before I go on, I will be clear about my Personal choices
I am convinced that intake of high amounts of oxidized highly processed soy, corn, grapeseed oil etc. are 'sub-ideal'
I never use in my own cooking, preferring ghee, avoid oil, EVOO, etc.
1/6) New Paper @NatMetabolism shows how fat cells in lean healthy mice and infants can change what would normally be an inflammatory signal into a beneficial one
Video: 2/6 Research team finds that young fat cells are resistant to inflammatory response to mtRNA (or synthetic analog) and INSTEAD respond with increased mitochondrial protein content
Basically, converts would-be inflammation into signal for new mitochondria!
1/ Thread🧵👇 2/ The study in question is a mouse study, as you can really perform these fine mechanistic study in animal models
Data show that genetics variation among mice was a minor contributor and the variations in microbiome composition were more important for physical performance...