1/10) 🚨NEW! #Keto for Anorexia🚨

We report on 3 patients who achieved remission from treatment-resistant anorexia using animal-based keto diet 🥩🍳

👉BMIs 10 - 13 kg/m2

👉Each gained ≥20kg

👉+Dramatic improvements in mental health

insulinresistance.org/index.php/jir/…

Read & Share🧵🙏 twitter.com/i/web/status/1… 2/10) Background 👇

Anorexia is a devastating condition that increases risk of death >5X and is associated w/ high rates of relapse

There is desperate need for more effective treatment options

1/ NEW RCT shows that Fat-Sugar mix

👉 Alters reward circuits in human brain

👉⬇️ preference for lower fat-sugar food and ⬆️ response to milkshake

👉These changes were independent of changes in body weight or metabolic health

... A thread🧵
cell.com/action/showPdf… 2/ In this study, normal-weight participants were exposed to EITHER a high-fat/high-sugar snack OR a low-fat/low-sugar snack for 8 weeks in addition to their regular diet. The snacks were to be consumed 2x per day and were isocaloric.

1/ As time has passed and positions have evolved, I’d like to do another thread 🧵 on Satiety Per Calorie (SPC) covering:

👉 Utility vs. Limitations

👉 Issues w/ messaging, “evolutionarily normal” “open-minded”

👉 And to get at sense of prevailing opinions (Poll!) 2/ First, I’d like to say I’m not against SPC as a HEURISTIC and ABSTRACT concept

Reflecting on what food nourishes and satisfies you is a good exercise, in line with mindful eating. That’s the utility!

🚨Carbohydrate insulin model “dead,” OR is it misunderstood again? 🤥

1/ Doctor Tweeted “that the carbohydrate-insulin theory is completely dead” ☠️⚰️

I recently watch the interview with that doctor, and it was surprising the degree to which s/he got the facts wrong… 2/ The CIM does posit that a high glycemic load diet drives high insulin to glucagon ratio state… as a result energy available in the bloodstream is driven downwards in the late postprandial phase leading to “hormonal, hunger” & overeating…

1/ How to poo 💩! Was listening to the new @hubermanlab with @DrGottfried this AM (at 3:37) on hormones and #constipation & was inspired to do a little thread on my top #6 tips for dealing with constipation ... hopefully this thread helps at least 1 silent sufferer 2/ This is a topic I'm interested in is bc as someone with a hx of proctitis + cecal patch (form of ulcerative colitis strongly linked to constipation), it's something I've struggled w/ at times. It's not fun & a far more prevalent problem than people realize 4 obvious reasons

1/4) “Satiety score” score suggest macadamia nuts are more likely to promote weight gain and prevent weight loss than cheesecake?! (higher = more satiety) 🧐

Macadamia = 17
Cheesecake = 19

Battered fried shrimp = 35
Apple juice = 32
Fried zucchini fritters 27

#satiety 2/4) First, lest address the science. Do macadamia nuts cause weight gain?

In a 4 week interventional trial in which people were instructed to eat 40-90 grams of macadamia there was actually a net weight loss.

Try getting those results with cheesecake…

#Satiety Science, thread! 🧵

1/ It seems the new trend is talking about food "satiety" scores

Superficially the approach makes sense… prioritize foods that’ll keep your full and thus you will lose weight. Sensible, right?

Maybe, or maybe not... 2/ 1st, satiety is an abstract concept

The best one can do is try to operationalize by creating scores based on other variables

@DietDoctor does this
[combines] "factors that make a food more satisfying: protein percentage, energy density, fiber content, and a hedonic factor."

1/4)🚨 WOW! SOO COOL!

NEW DATA in @CellCellPress show that light can directly alter human glucose tolerance via a light-eye-brain-brown fat axis 🧠

5 min video:
ht/ @hubermanlab 2/4) Using 🐁 model researchers show light impairs brown fat thermogenesis and glucose tolerance directly via axis composed of:
I) photo-sensitive retinal ganglion cells
II) supraoptic nucleus
III) paraventricular nucleus
IV) nucleus solitary tract
V) rostal raphe nucleus

1/6) This TW screenshot has received a lot of traction

Personally, I read it as "ketosis itself doesn't enhance weight loss, as compared to carbohydrate restriction without ketones >0.5mM."

Nevertheless, I think this is an interesting topic. So... THREAD!
@DrEenfeldt 2/6) First, consider weight loss. RCT data show that carbohydrate restriction can increase total energy expenditure in a dose-response manner

Thus, ketogenic - be virtue of being very low carb - may have an edge in terms of energy expenditure

pubmed.ncbi.nlm.nih.gov/30429127/

Weight loss drugs for kids!

1) As you may have heard, the FDA has approved the weight loss drug semaglutide (a GLP-1 agonist) for kids 12 and older with #obesity

Good? Bad? I wanted to do a thread 🧵on the STEP TEENS data with some thoughts...

PLZ READ IN FULL 2) Semaglutide Treatment Effect in People (STEP) with obesity TEENS trial was a double-blind RCT that lasted 68 weeks & included kids 12-18 years. 180 completed the trial

Baseline means:
-Mean age was 15.4 years
-BMI = 37
-Weight = 237lbs
nejm.org/doi/full/10.10…

1/18) 🚨NEW PAPER in @AJCN provides evidence supporting #CIM of #obesity

👉 Glycemic Load >>> Calorie Counting for weight loss

👉 Biomarkers of Low carb diet predict weight

👉Insulin hyper-secreters especially benefit fromlow-carb

Video 👉👉
🧵... 2/18) First, and foremost, a big congrats to @AdrianSotoMota and @davidludwigmd for an excellent work!

& of course, for those who have the time, I highly recommend reading the full paper, here: doi.org/10.1016/j.ajcn…

But for those who prefer video or TW thread... HERE WE GO...

New Year #Egg 🥚Hacks

(1/3) Cream Crispy

Pour heavy cream in bottom of a non-stick pan & sprinkle w/ salt

Add eggs

Watch as cream boils & caramelizes the edges and converts to butter 🧈

Result = Caramelized whites with Creamy runny yolks and rich brown butter aroma! (2/3) Cream Brown-Butter Scrambled

Heat just 1 Tbsp cream skillet & let it cook until well caramelized

Then add a 2-3 Tbsp of fresh cold cream to rapidly reduce the temperature of the pan, stirring to re-emulsify fat

Streamed in beaten eggs

My YouTube w @KenDBerryMD on #Entomophagy has gotten 🔥 responses!

Should I back off? Probs

But instead, I CHALLENGE YOU 🫵 to put aside emotions & watch 1 of these videos

11 m:
45 m:

1/ NOW for 🧵 on 5 MYTHS about eating Bugs! A DISCLAIMER

I am NOT trying to take your meat
I am NOT saying meat is unhealthy
I am NOT trying to force you to eat bugs
I am NOT trying to force you to eat bugs
I am NOT trying to force you to eat bugs

I AM asking you to set aside emotion and have an open mind

Begin...

🚨Fascinating NEW peer-reviewed report provides transparency on the "Corporate Capture” of the Academy of Nutrition and Dietetics

👉 Undisclosed conflicts

👉 Bias in public health policy

👉 Money > Health
🧵Thread + Review & Reaction video (5m): 2/ Academy of Nutrition & Dietetics (AND) comprises largest US organization of nutrition professionals: >100,000 dietitians/students

Group goal: “accelerate improvements in global health and well-being through food and nutrition”

AND = authority helping set food policies

#Vegan🌱#keto (low sat fat, 0 cholesterol)
vs.
Meat and Egg heavy diet + 120g net carbs

N=1 Crossover experiment

Surprisingly, LDL >300 mg/dL on vegan keto and ~100 mg/dL on meat and egg plus carb diet 🤯

👉 If this doesn't make you curious, I don't get you 2/ This contradicts the explanation that sat fat is the primary driver of ⬆️ LDL on low-carb

While it may represent an outlier case (& sat fat may primarily drive⬆️LDL in others), that these lipid results can present in anyone requires an explanation beyond conventional wisdom

1/7)🤯 New study in PNAS shows low-doses of sweetener aspartame can produce anxiety behavior 🧠in mice that's TRANSMITTED to their children and grandchildren 👦👶

Video:

Thread 🧵👇

https://twitter.com/hubermanlab/status/1605470819966013440

2/7) The first experiment the team performed in this study was to expose male & female mice to normal drinking water or water with 0.015-0.03% aspartame

Notably this dose is only 7/8-15% the FDA recommended max dose for human intake, and the equivalent of 2-4 diet sodas per day

Thread🧵on Seed Oils that will please Nobody😲

1/10) First, why this thread?

Because I've seen seed oils rise quickly as a perceived villain within (and outside) the low-carb community as a presumed critical cause of metabolic dysfunction

Is this the case? ... 2/10) Before I go on, I will be clear about my Personal choices

I am convinced that intake of high amounts of oxidized highly processed soy, corn, grapeseed oil etc. are 'sub-ideal'

I never use in my own cooking, preferring ghee, avoid oil, EVOO, etc.

STUNNING! #Mitochondria Judo 🥋!

1/6) New Paper @NatMetabolism shows how fat cells in lean healthy mice and infants can change what would normally be an inflammatory signal into a beneficial one

⬆️mito-biogenesis

⬆️thermogenesis

❌#obesity

Video: 2/6 Research team finds that young fat cells are resistant to inflammatory response to mtRNA (or synthetic analog) and INSTEAD respond with increased mitochondrial protein content

Basically, converts would-be inflammation into signal for new mitochondria!

🚨New paper in @Nature reveals link between #microbiome & #exercise motivation!🧠🐁

👉Provides foundational insight that could lead to dietary practices & supplements to promote exercise motivation

Video:

@hubermanlab
#dopamine

1/ Thread🧵👇 2/ The study in question is a mouse study, as you can really perform these fine mechanistic study in animal models

Data show that genetics variation among mice was a minor contributor and the variations in microbiome composition were more important for physical performance...

Is fruit healthy? 🍌🍉🍇🥭🍓

Thread 🧵...

1/ Some argue most fruit has sugar. Sugar is bad. Therefore, fruit is not a health food

Others may argue that fruit is natural; therefore, universally healthy.

Both perspectives are oversimplifications... 2/ IMO, the question of fruits' healthfulness can be assessed based on primarily on 3 principles:

(i) - Nutrient density vs glycemic impact

(ii) - Metabolic profile of the consumer

(iii) - What's the "control?"

🚨Cool New Study!

Omega-3 fats have sex-specific impacts on lipids, LDL, HDL & TG!

Thread + video breakdown...

1/ In this new paper published in the @LipidJournal, researchers performed a Double-Blinded Randomized Crossover to see how EPA & DHA imapct lipids and mean dn women 2/ The study was a has 21 subjects each with at least 1 marker of Metabolic Syndrome

There was a 4 week run-in period, followed by 10w on 3g/d of EPA or DHA, a washout period, and then the other long-chain fatty acid. Again, order was randomized and study was double-blinded...