Very happy to announce a new EU collaborative project aiming at improving tumor genome interpretation for precision/personalized cancer treatment. Want to know more? Here a short thread 🧵 After sequencing the tumor genome (or a gene panel) a list of cancer mutations are identified; for the clinician it is key to know which ones are cancer driver mutations or biomarkers of drug response, as this information may determine the treatment decision for the patient.

Very happy to announce a major IntOGen update. This new version contains a comprehensive and reliable compendium of cancer genes and their mutational features across 61 tumour types, obtained by analysing 26,955 cancer genomes intogen.org. Thread 👇 How does intOGen identify cancer genes?

Briefly, intOGen runs six complementary driver discovery methods that analyze the pattern of mutations per gene and cohort and combines their output to produce a compendium of driver genes and a repository of their mutational features

Our manuscript describing a 10bp mutation rate periodicity within nucleosome-covered DNA is out in @CellCellPress. [1/11]
authors.elsevier.com/a/1X~jBL7PXUj6c We found that tumor somatic mutation rate has a strong 10bp periodicity, which follows the orientation of the DNA minor groove towards or away from histones. [2/11]