We are so excited to finally share our new study reporting the evolution of cross-resistance between targeted therapy and immunotherapy, published today @NatureCancer. Highlights in the 🧵👇 Free access here rdcu.be/coKr9 1/25 Targeted therapies (TT) and immunotherapies (IT) have revolutionized the treatment of cancer patients and these therapies are often administered sequentially. But how do these therapies shape the tumor and influence the subsequent treatment response? 2/

We are so excited to present our functional #lineagetracing tool, CaTCH, developed in the @obenaufa lab @IMPvienna published @naturebiotech. Have you ever wondered if a phenotype is pre-existing in a cell or whether it is acquired during selection? Then👇might be your tool!1/14 CaTCH - short for “CRISPRa Tracing of Clones in Heterogeneous cell populations” - combines precise mapping of the lineage history of millions of cells with the ability to isolate any given clone alive from a complex population based on genetic #barcodes. 2/14