DNA writing tools have revolutionized genome editing

but how do we make any possible edit, insertion, or deletion in RNA safely?

Today we report on a novel RNA writing tool, PRECISE editing, that allows you to make any edit in RNA. w/ @jgooten 🧵👇🏼

1/18biorxiv.org/content/10.110… To develop PRECISE editing

we leverage trans-splicing, a natural reaction that allows separate RNA molecules to splice into each other

enabling splicing between trans exons rather than cis exons. 2/18

Today we report in @biorxiv programmable RNA sensors that express any protein gated on specific RNAs in a cell. Much like gene sequencing necessitated gene editing tools, we answer “What is the Cas9 of single cells?” 🧵👇🏼w @jgooten & @insitubiology 1/17 biorxiv.org/content/10.110… Genome sequencing needs gene editing to probe insights gained from the data. With the advent of single-cell RNA seq (h/t @humancellatlas), there is now a similar need for cell type targeting at the RNA level. We tackle this with RADARS, a programmable way to target cells 2/17