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Pouya Alexander Ameli, MD MS Profile picture
Pouya Alexander Ameli, MD MS
@pouyeah
Professor, Neurologist 🧠, ICU Doc #neurocritcare #zentensivist @UFHealth | Foodie 😋 | Amateur Gardener 👨🏽‍🌾 | First gen | 3rd culture kid 🇺🇸🇮🇷🗺️
Jun 16, 2021 • 5 tweets • 4 min read
#TTM2 trial showing no difference in OHCA management with hypothermia (33C) vs. Normothermia (Target 37.5C if temp reach 37.8C or higher).

- Mortality
- mRS
- QoL (EQ-5D-5L)

All no significant difference.

But hypothermia = more arrhythmia (24% vs. 16%)

nejm.org/doi/full/10.10… Trying to figure out how to reconcile this with prior data favoring hypothermia? A few points re: TTM2:

- Only stable arrest (>20mins)
- Shockable rhythm >70%
- Average Lactate just below 6
- 54% of patient in normothermia group never had a temp >37.8C (never required cooling)