Physician Scientist/MSKCC. All views expressed here are my own & do not represent my employer.
COI:https://t.co/yXttSKlaik
May 19, 2022 • 14 tweets • 5 min read
Part 2 of the GOLDI-lox preprint set, led by @andrewdunbar_md and @bowman_rl. Q: If you had a system which can test oncogenic dependency in context of co-mutant disease alleles, what question would you ask? For us, it was simple; JAK2V617F! #mpnsm biorxiv.org/content/10.110…
The role of JAK2V617F in MPN pathogenesis has long been demonstrated, and expression of JAK2V617F induces MPN in vivo as shown by many groups including @mullallylab, Tony Green, Radek Skoda, and Jean-Luc Villeval.
As this year ends, some reflections from an (increasingly) grey-haired physician scientist. THREAD
1. Never has it been more important to be part of a community, whether in your lab, department/program, and/or scientific field. It is our source of strength and resilience.
Oct 9, 2021 • 7 tweets • 2 min read
Devastated to hear that Eli Estey passed away. Sending profuse condolences to his family and to his Hutch/UW/MDACC family.
1. Eli was the person who always asked the hard question, and made the presenter/audience think.
May 14, 2021 • 9 tweets • 1 min read
How do you choose a mentor and a lab. Here are some questions you should ask current lab members... THREAD
1. How often do you meet with your PI one on one? is it regularly scheduled or do you need to arrange?
Jan 2, 2021 • 9 tweets • 1 min read
Senior investigators/laboratory researchers->what are you going to do in 2021 to support emerging leaders in your field, in particular those outside your inner mentorship zone?
Here is what I am going to do. THREAD
1. Schedule every other week zoom lab meetings with other labs in the field focusing on junior faculty at other institutions. Follow up these meetings with new collaborations and career development discussions with the PI and lab members of the lab which joins us.
Dec 16, 2020 • 17 tweets • 2 min read
Now that we have all seen some light at the end of the tunnel, how do we approach 2021 as PIs? Some thoughts on the next 6-9 months
1. Everyone is tired and weary; mentally, physically and emotionally. Whether from delays/shutdowns relating to lab/clinical research, home schooling/child-care challenges, a F&^|G pandemic->its been exhausting for everyone.
Nov 23, 2020 • 17 tweets • 4 min read
Finishing up 2 weeks on inpatient (non-COVID, largely) service. Reflecting back, particularly in light of my friend David Weinstock's perspective on being a physician scientist involved in clinical care; nejm.org/doi/full/10.10…
My two cents
1. I had a great experience being an inpatient leukemia attending the last two weeks. Great colleagues, really touching interactions with patients and their families, and I learned a lot as always.
1. You are the consummate scientist, and you and your group's contributions to cancer epigenetics, leukemia biology, epigenetic therapies, and immune-oncology are original, impactful, and greatly influence how we think about cancer biology and do our own work.
Oct 26, 2020 • 13 tweets • 3 min read
Part 2 of an awesome week of great collaborative studies coming out; the Beat AML Master Trial! An amazing effort led by Amy Burd @LLSResearch , John Byrd @OSUCCC_James , Brian Druker @OHSUNews and myself @SloanKettering.
nature.com/articles/s4159…
1.This study started in a small hotel conference room at ASH 2015; a group of us got together and wondered if it was time for a genomic-guided clinical trial in AML. The LLS and their CEO @LouisJDeGennaro saw the possibility, and challenged us to make it happen
Mar 11, 2020 • 7 tweets • 1 min read
PIs. ask yourself and your lab some important questions today. 1. If someone can do their job at home (or part of their job), are you letting them do it? 2. Did you freeze down aliquots of your ongoing cell culture experiments in case you have to stop ongoing experiments?
3. Is your animal colony tightly maintained, and can a "skeleton" crew of people from the lab take turns maintaining it if needed?
Jan 22, 2020 • 9 tweets • 2 min read
One of the hardest things to figure out as a PI, especially a young PI, is "when to hold em and when to fold em" with respect to appealing/revising a paper with tough reviews. A few thoughts
1. Don't ever figure this out alone, or even just within your lab. Ask peers, mentors and THE EDITOR if the revision is feasible
Jan 20, 2020 • 17 tweets • 4 min read
The chalk talk; my own personal two cents... 1. The goal of a chalk talk is not to show how much you know, or to show all the ideas and projects you can think or or actually accomplish
2) It is to show
A. feasible research plan which will lead to results, papers and grants
B. ability to take in others' ideas/questions, to respond thoughtfully and engage the people in the room in a back and forth
C. get everyone in the room excited to have you as a colleague
Jan 16, 2020 • 11 tweets • 2 min read
It is now interview season! a few thoughts for those going on job interviews for lab based PI positions. 1) Get there the night before the interview, even if no dinner. If no dinner scheduled and you have a friend there, go out for a bite and get the real scoop
2) Look at one paper from each person you will meet, and get the overall gist. If the conversation in any one-on-one stalls, ask them about this paper and their work! we all love to talk about our own science and you can soak it in...
