🧵𝗡𝗮𝘁𝘁𝗼𝗸𝗶𝗻𝗮𝘀𝗲: 𝗘𝘃𝗲𝗿𝘆𝘁𝗵𝗶𝗻𝗴 𝘁𝗵𝗲𝗿𝗲 𝗶𝘀 𝘁𝗼 𝗸𝗻𝗼𝘄

𝗧𝗵𝗲 #𝟭 𝗲𝗻𝘇𝘆𝗺𝗲 𝗳𝗼𝗿 𝗼𝗽𝘁𝗶𝗺𝗶𝘀𝗶𝗻𝗴 𝗰𝗮𝗿𝗱𝗶𝗼𝘃𝗮𝘀𝗰𝘂𝗹𝗮𝗿 𝗵𝗲𝗮𝗹𝘁𝗵.

Nattokinase breaks blood clots, reverses atherosclerosis, lowers blood pressure, and optimizes lipid profiles. Disclaimer: None of this is medical advice and this is for educational purposes only.

𝗗𝗘𝗘𝗣 𝗗𝗜𝗩𝗘 𝗢𝗡 𝗧𝗛𝗜𝗔𝗠𝗜𝗡𝗘 𝗙𝗢𝗥 𝗠𝗜𝗧𝗢𝗖𝗛𝗢𝗡𝗗𝗥𝗜𝗔𝗟 𝗛𝗘𝗔𝗟𝗧𝗛

Vitamin B1, also known as thiamine, plays crucial roles in many metabolic processes and cellular functions.

🧵Let's dig in.... Thiamine acts as a cofactor for important enzymes, including:

- Cytosolic transketolase
- Pyruvate dehydrogenase (PDH)

Both of these are essential for effective energy metabolism. And energy metabolism is king.

Do you need to take omega-3 supplements if you eat adequate amounts of seafood?

There is plenty of research emphasizing the importance of omega-3s PUFAs such as EPA & DHA, but are natural sources enough?

Let's take a look... 🧵
Typically supplements will provide 1-2g of omega-3s...

But how much can we get from whole foods?

Taurine & Mitochondrial Function

In in-depth🧵exploring how taurine improves mitochondrial health, and why it matters for metabolic disease, diabetes and heart disease. Taurine is a semi-essential amino acid that can be synthesized from methionine and cysteine using vitamin B2,3 & 6 as cofactors.

Testosterone & Leptin

Leptin is one of the master hormones that actively regulate myriad other hormones including the thyroid, adrenal, pancreatic and sex hormones.

THREAD 🧵 Leptin controls energy metabolism within the body on a macro scale. As with most things in biology, it is not good or bad, the story lies in restoring coherence, and re-establishing leptin sensitivity.

Grounding & Blood Clots

A 🧵 on why zeta-potential maxxing matters if you want to avoid blood clots. Zeta potential is the electrostatic difference between the surface of a solid particle and the liquid within which it is immersed.

Nutrition for Mitochondrial Function Omega Thread:

This 🧵will shine a light on why I prioritise micronutrient density.

Mitochondrial function relies on optimal nutrient levels as they play pivotal roles in driving energy metabolism and ATP production.

(Bookmark this)

THREAD

Several vitamins and minerals are crucial for mitochondrial function serving as cofactors in energy metabolism or exerting antioxidant effects.

High Protein To Lose Weight:

Everyone always says that a high protein diet is beneficial for weight-loss, but never tell you why...

This 🧵will explore all of the mechanisms behind protein's weight-loss benefits. The WHO recommends that protein should constitute 10-15% of energy intake... but this may not be enough.

A high protein diet is considered to contain 20-30% of energy intake from protein.

1 gram of protein per pound of body weight is a great benchmark.

Taurine & Mitochondrial Function

In in-depth🧵exploring how taurine improves mitochondrial health, and why it matters for metabolic disease, diabetes and heart disease. Taurine is a semi-essential amino acid that can be synthesized from methionine and cysteine using vitamin B2,3 & 6 as cofactors.

A Guide on Near-Infrared Light

This 🧵covers the details of our natural light environment and the optics that the human body has evolved to take advantage of it.

Light is life... let me show you how. The sun represents the single largest energy input to the human body with a solar spectrum extends between 250-4000nm.

Chronobiology & Sleep Patterns:

This 🧵explores the science of chronotypes and how our artificially lit modern world is nuking our sleep and circadian health.

If you stare at a screen at night, sleep late and wake up tired, this will apply to you. Structure of the Thread:

1) Intro to Chronotypes
2) Modern Environmental Mismatch
3) Re-Syncing with a Natural Environment
4) How to Advance your Circadian Phase

The Mitochondrial Origin for Type 2 Diabetes Mellitus

This 🧵will explore the thesis that insulin resistance and subsequent T2DM is caused by mitochondrial dysfunction.

In a previous thread I described Douglas C. Wallace's "Mitochondrial Paradigm for Chronic Disease".

Now it is time to tell a story of how exactly this manifests in T2DM.

x.com/sam_soete/stat…

Vitamin K Omega Thread:

Want to know why everyone combines vitamin D supplementation with vitamin K?

This 🧵goes deep into the mechanisms of action of vitamin K, and its synergistic relationship with vitamin D in preventing vascular calcification and maintaining BMD. This thread will cover:

• Types & sources of vitamin K
• Causes of vitamin K deficiency
• Vitamin K & bone health
• Vitamin K & vascular calcification/CVD
• Interaction b/w vitamin K & D

Mitochondria lie at the heart of chronic, neolithic disease.

This 🧵explores the mitochondrial paradigm of degenerative disease pioneered by Doug Wallace.

This shit is interesting... And the implications are unimaginable. Chronic disease is not a genetic story.

Genetic mutations cannot explain the meteoric rise of chronic disease in recent decades. The problem lies not in our genes, but in our environment.

Vitamin B12 Deficiency 🧵

Micronutrients > Macros & Calories

But what is the point if your body can't effectively absorb or retain these nutrients?

Let's take a look why you may have a vitamin B12 deficiency. Let's get the easy wins out of the way first.

1) Vegetarian or vegan diets

Leptin Sensitivity & Melatonin Are Intertwinned:

This is an unbelievably important connection to understand.

Let's dive into why & how a deficiency in melatonin production can lead to leptin resistance = obesity, nuked metabolism & chronic hunger. Melatonin production does not only prepare the body for restorative sleep, but it helps regulate energy homeostasis through food intake, energy storage & energy expenditure.

How I fixed my lower back pain:

For the past 11 months I have struggled with debilitating chronic lower back pain. It is gone now.

This 🧵explains the pitfalls, revelations and lessons I learned to overcome it. There was no injury, no accident, no obvious cause for my pain.

Over several days my lower back developed extreme stiffness and pain on leaning forwards and bending down.

Wtf.

The interplay of light, circadian rhythms, and sleep on ADHD symptoms.

This 🧵delves into the interplay between these factors and their underlying mechanisms.

Followed by 9 actionable steps to minimise their effect on your ADHD symptoms. Lets take a quick look at how our circadian rhythms are entrained.

How I transformed from a devitalized medical student to a decentralized doctor.

A cathartic 🧵 about my story through medical school and life.

This is a deeply personal compilation of self-reflections.

I trust you. Throughout medical school, the most frequent question I was asked was:

"What specialty do you want to go into?"

Is the FDA compromised?

A 🧵looking into their questionable approval of Recarbrio, a novel antibiotic combination. Following the thalidomide tragedy in the 1960s, the US mandated drug makers to furnish "substantial evidence" of drug effectiveness.

Seed Oils Are Nuking Your Mitochondria:

This 🧵explores the underlying mechanisms underpinning the consumption of Ω-6 fatty acids and mitochondrial dysfunction. The unprecedented consumption of seed oils represents one of the biggest changes to our diet in the last century.

The Diet-Heart Hypothesis manipulated people into consuming polyunsaturated fatty acids (PUFAs) and struck fear in their hearts with regards to saturated fat.