Nutrition for Mitochondrial Function Omega Thread:

This 🧵will shine a light on why I prioritise micronutrient density.

Mitochondrial function relies on optimal nutrient levels as they play pivotal roles in driving energy metabolism and ATP production.

(Bookmark this)

THREAD

Several vitamins and minerals are crucial for mitochondrial function serving as cofactors in energy metabolism or exerting antioxidant effects.

High Protein To Lose Weight:

Everyone always says that a high protein diet is beneficial for weight-loss, but never tell you why...

This 🧵will explore all of the mechanisms behind protein's weight-loss benefits. The WHO recommends that protein should constitute 10-15% of energy intake... but this may not be enough.

A high protein diet is considered to contain 20-30% of energy intake from protein.

1 gram of protein per pound of body weight is a great benchmark.

Taurine & Mitochondrial Function

In in-depth🧵exploring how taurine improves mitochondrial health, and why it matters for metabolic disease, diabetes and heart disease. Taurine is a semi-essential amino acid that can be synthesized from methionine and cysteine using vitamin B2,3 & 6 as cofactors.

A Guide on Near-Infrared Light

This 🧵covers the details of our natural light environment and the optics that the human body has evolved to take advantage of it.

Light is life... let me show you how. The sun represents the single largest energy input to the human body with a solar spectrum extends between 250-4000nm.

Chronobiology & Sleep Patterns:

This 🧵explores the science of chronotypes and how our artificially lit modern world is nuking our sleep and circadian health.

If you stare at a screen at night, sleep late and wake up tired, this will apply to you. Structure of the Thread:

1) Intro to Chronotypes
2) Modern Environmental Mismatch
3) Re-Syncing with a Natural Environment
4) How to Advance your Circadian Phase

The Mitochondrial Origin for Type 2 Diabetes Mellitus

This 🧵will explore the thesis that insulin resistance and subsequent T2DM is caused by mitochondrial dysfunction.

In a previous thread I described Douglas C. Wallace's "Mitochondrial Paradigm for Chronic Disease".

Now it is time to tell a story of how exactly this manifests in T2DM.

x.com/sam_soete/stat…

Vitamin K Omega Thread:

Want to know why everyone combines vitamin D supplementation with vitamin K?

This 🧵goes deep into the mechanisms of action of vitamin K, and its synergistic relationship with vitamin D in preventing vascular calcification and maintaining BMD. This thread will cover:

• Types & sources of vitamin K
• Causes of vitamin K deficiency
• Vitamin K & bone health
• Vitamin K & vascular calcification/CVD
• Interaction b/w vitamin K & D

Mitochondria lie at the heart of chronic, neolithic disease.

This 🧵explores the mitochondrial paradigm of degenerative disease pioneered by Doug Wallace.

This shit is interesting... And the implications are unimaginable. Chronic disease is not a genetic story.

Genetic mutations cannot explain the meteoric rise of chronic disease in recent decades. The problem lies not in our genes, but in our environment.

Vitamin B12 Deficiency 🧵

Micronutrients > Macros & Calories

But what is the point if your body can't effectively absorb or retain these nutrients?

Let's take a look why you may have a vitamin B12 deficiency. Let's get the easy wins out of the way first.

1) Vegetarian or vegan diets

Leptin Sensitivity & Melatonin Are Intertwinned:

This is an unbelievably important connection to understand.

Let's dive into why & how a deficiency in melatonin production can lead to leptin resistance = obesity, nuked metabolism & chronic hunger. Melatonin production does not only prepare the body for restorative sleep, but it helps regulate energy homeostasis through food intake, energy storage & energy expenditure.

How I fixed my lower back pain:

For the past 11 months I have struggled with debilitating chronic lower back pain. It is gone now.

This 🧵explains the pitfalls, revelations and lessons I learned to overcome it. There was no injury, no accident, no obvious cause for my pain.

Over several days my lower back developed extreme stiffness and pain on leaning forwards and bending down.

Wtf.

The interplay of light, circadian rhythms, and sleep on ADHD symptoms.

This 🧵delves into the interplay between these factors and their underlying mechanisms.

Followed by 9 actionable steps to minimise their effect on your ADHD symptoms. Lets take a quick look at how our circadian rhythms are entrained.

How I transformed from a devitalized medical student to a decentralized doctor.

A cathartic 🧵 about my story through medical school and life.

This is a deeply personal compilation of self-reflections.

I trust you. Throughout medical school, the most frequent question I was asked was:

"What specialty do you want to go into?"

Is the FDA compromised?

A 🧵looking into their questionable approval of Recarbrio, a novel antibiotic combination. Following the thalidomide tragedy in the 1960s, the US mandated drug makers to furnish "substantial evidence" of drug effectiveness.

Seed Oils Are Nuking Your Mitochondria:

This 🧵explores the underlying mechanisms underpinning the consumption of Ω-6 fatty acids and mitochondrial dysfunction. The unprecedented consumption of seed oils represents one of the biggest changes to our diet in the last century.

The Diet-Heart Hypothesis manipulated people into consuming polyunsaturated fatty acids (PUFAs) and struck fear in their hearts with regards to saturated fat.

Mitochondria: An Epic Origin Story

What are they? Where do they come from? And why are they here?

This 🧵unravels the mystery behind the origins of the most important and enigmatic organelle in our body.

#mitochondria #metabolism #science #biology In the depths of time, when the universe was but a tender babe, an epoch unfathomable, there existed naught but primordial cells.

1.5 billion years ago, a singular ancient invasion by a eubacteria of an archea host occurred.

Master Thread on Statins: The Four Horsemen

1) How statins nuke your mitochondria

2) How statins cause T2DM

3) How statins cause CVD

4) How statins cause cardiomyopathy

#statins #bigpharma

https://twitter.com/sam_soete/status/1657013095510966272?s=20

𝗦𝘁𝗮𝘁𝗶𝗻𝘀 destroy your skeletal muscle, why would they be any good for your 𝗵𝗲𝗮𝗿𝘁?

This 🧵 dives deep into mechanisms underlying statin induced cardiomyopathy.

#statins #cardiomyopathy #CHF #heartfailure #health #bigpharma Over 64 million people suffer from heart failure worldwide.

To what extent is statin therapy contributing to the epidemic of congestive heart failure (CHF) worldwide?

Statin cardiomyopathy is a complication that can occur in 1-3% of people.

The Art of War:

According to an old story, a lord of ancient China once asked his physician, a member of a family of healers, which of them was the most skilled in the art. The physician, whose reputation was such that his name became synonymous with medical science in China, replied, “My eldest brother sees the spirit of sickness and removes it before it takes shape, so his name does not get out of the house.

Unveiling the Paradox: Do Statins Fuel the Fire of Heart Disease?

This is a deep dive 🧵into the mechanistic relationship between statins and coronary heart disease.

#statins #CVD #heartdisease #cholesterol #mitochondria The ‘bad & good cholesterol hypothesis’ has lost its foundation.

Although lowering the LDL-C/HDL-C ratio is possible with drugs such as statins, this is not effective in preventing cardiovascular disease (CVD).

Statins, given like Halloween candy to those with >10% risk of CVD, can cause insulin resistance & diabetes.

A prime example of "double think".

This 🧵 explores how statins impede insulin sensitivity & damage our pancreas.

#statins #diabetes #T2DM #CVD #cholesterol Let's start off by reminding ourselves that diabetes and the broader category of metabolic syndrome is one of the leading risk factors for CVD.

Any drug that claims to be protective of CVD, should not be impeding insulin sensitivity.