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Will Profile picture
Will
@sandakano
Postdoc w/ @BeEngelhardt studying machine learning, genomics, & neuroscience. Biostatistics PhD w/ @rafalab. Ex-tropical ecologist. High pointing enthusiast.
Mar 12, 2019 • 16 tweets • 7 min read
Do you work with single cell RNA-Seq data (or any count data with large numbers of zeros)? You may be interested in our preprint now available on @biorxiv_genomic : biorxiv.org/content/10.110… in collaboration with @rafalab @stephaniehicks and Martin Aryee I will try to describe here the main points. 1. Sampling distribution of unique molecular identifier counts (UMI) is NOT zero inflated (see also nxn.se/valent/2017/11… from @vallens ). Apparent zero inflation in read counts is due to PCR duplicates.