Sean Kelly Profile picture
Building my 4th 8-figure biz (B2B media holdco). Also GP & Investor at The Family Fund VC. Biomed engineer too. Helping founders achieve breakout performance.
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Apr 15 16 tweets 5 min read
In 1879, one man made an invention that shaped the modern world.

But accidentally sabotaged our health...

It disrupts sleep, triggers disease, and increases death risk by 34%—yet we can't live without it.

Here's what scientists discovered about its impact on human longevity:🧵 Image Thomas Edison invested $40,000 (about $850,000 today) to create the first practical light bulb.

That investment was astronomical...

But it led to his breakthrough:

In October 1879, his lamp burned for 2 days, which was incredible at the time, and that paved the way...
Apr 9 16 tweets 5 min read
The world's most powerful people are impossible to reach.

No email, no SMS, no Instagram.

Meanwhile, the average person loses 40% of their workday to interruptions.

Here's the solution that might be your most valuable career move (it's so simple you'll laugh): Image Warren Buffett's calendar is basically empty.

Elon Musk structures his day in 5-minute blocks.

Jeff Bezos only handles decisions requiring significant judgment.

This isn't a coincidence; it's a deliberate strategy that separates extraordinary achievers from everyone else...
Apr 3 14 tweets 4 min read
This is the hidden curse of successful people.

It destroys motivation, crashes dopamine, and breaks high performers—right when they're winning.

Recently, I've analyzed this achievement paradox.

What I found is shocking 🧵 Image Success feels amazing at first.

Each win floods your brain with dopamine—the "motivation molecule" that drives motivation and reward.

But there's a dark side to this rush that nobody talks about.

A hidden trap that ensnares high performers when they least expect it...
Mar 28 16 tweets 5 min read
Meet Steve Job's arch-enemy:

Money.

His $7 billion fortune couldn't save him from one fatal medical mistake.

Here's how having unlimited resources can impact your lifespan: 🧵 Image Jobs revolutionized technology, building Apple into the world's most valuable company.

He amassed a $7 billion fortune and became Disney's largest shareholder through Pixar.

Yet in October 2003, he received news that would change everything:
Mar 20 17 tweets 6 min read
Singapore will jail you for 15 years if you use chemicals in food.

But most of America probably ate it for breakfast.

It's found in yoga mats, shoe soles, and...our BREAD.

Here's the disturbing reason why the FDA allows this banned substance in your sandwich:🧵 Image It's called azodicarbonamide (ADA).

And it's not just in your breakfast bread.

It's in bagels, pizza dough, pastries & more. It's EVERYWHERE.

Singapore banned it for good reason, here's what I mean:
Mar 18 17 tweets 6 min read
Looking at your phone is adding 600+ pounds of pressure to your neck every day.

Causing chronic nerd neck...

It's destroying your spine, making you tired, bald and dumber.

Here's ONE exercise you can do to reverse years of damage (takes 15 seconds):🧵 Image Your head weighs about 12 pounds when perfectly aligned.

But tilt it forward 60 degrees to look at your phone?

That weight multiplies to 60 pounds of pressure on your spine.

And if you happen to be a normal human you're probably f*cked... Image
Mar 6 22 tweets 7 min read
This is crazy.

People living in Europe never get sick & live to 100+ while:

• Eating a sh*t load of carbs
• Drink alcohol daily
• Barely exercising

But when Americans do it? They get obese and burn out.

I had to find out what was going on... 🧵 Image My search led me to something fascinating: "Blue Zones."

These are special regions where people consistently live to 100 and beyond.

They're not just surviving––but thriving.

And what's wild?

They defy everything we think we know about health...
Feb 27 20 tweets 6 min read
You'll probably lose your job to AI in the next 5 years.

By 2030, no one will care about your:

• Education
• Niche skills
• Years of experience

But there's ONE thing you can do today to become irreplaceable:🧵 Image Enter the "T-shaped" expert.

Someone with:

• Deep expertise in ONE core domain
• High-level knowledge in related fields
• The ability to bridge these worlds effectively

Developing this kind of expertise has never been more crucial... Image
Oct 30, 2024 15 tweets 5 min read
Before the 1970s, everyone was hot & healthy. People ate more, smoked more, and exercised less.

And they still managed to stay fit and healthy without going low carb, avoiding dessert, or fasting.

But since then, obesity has increased almost 5x. Here's what went wrong: Image 73% of adults in the US are overweight
34% of adults in Italy are overweight

Italians are eating pizza, pasta, butter, and drinking lots of wine -- but they have only half as many people who are overweight compared to the US. Image
Oct 10, 2024 17 tweets 5 min read
Japan has over 52,000 companies that are 100-plus years old while the US has barely a thousand such businesses.

These ancient companies called ‘Shinise’ in Japanese unconsciously figured out the philosophy of the big question: "How to run a company"

THREAD Image The average lifespan of a US S&P 500 company is just 15 years, and McKinsey predicts 75% of them will disappear by 2027 (!!)

Company lifespans are getting shorter & shorter.

Yet, Japan is home to 8 of the world’s 10 longest-running businesses, all founded before 800 AD. Image
Oct 6, 2024 15 tweets 5 min read
In 2008, I almost sold my company to Zappos.

I got to know Tony Hsieh and members of his team, hanging out at his office & his favorite spots like the Foundation Room.

Tony passed away in 2020, but what he taught me about company culture will stay with me forever.

A thread 🧵 Image But first, a little backstory...

Our eComm co Fit Fuel was going to be part of Zappos.

We spent dozens of hours discussing everything.

But timing can be cruel.

It was the fall of 2008, and the world was about to witness one of the greatest financial collapses.
Oct 3, 2024 19 tweets 5 min read
Ketones are the greatest (legal) performance-enhancing "drug".

Your brain, heart, and metabolism greatly prefer ketones as a fuel source.

They are the reason you remain cognitively sharp while fasting.

Here's what everyone needs to know: 🧵 Image First off, what is a ketone?

It's a byproduct of fat being burned and serves as an alternative fuel source to glucose.

Think of ketones as your backup energy reserve when glucose is depleted.

Once that happens...
Oct 1, 2024 18 tweets 6 min read
Larry Ellison is the craziest CEO alive:

• Hired investigators to spy on Microsoft
• Waged a decade-long war against Google
• Plotted to buy Apple and make Steve Jobs the CEO

At 80, he looks younger than most 50-year-olds.

How he managed to do this is insane 🧵 Image Ellison was a close friend of Steve Jobs. When Jobs was thrown out of Apple in 1985, Ellison stood by him.

He plotted to buy Apple, make Steve Jobs the CEO, and give him 25% of the company.

But Jobs refused. Here's Ellison talking about it 👇
Sep 29, 2024 16 tweets 5 min read
5 hard-to-believe truths about the human body I learned after biohacking for the last 20 years: 🧵

1. You don't need to work out your abs to get a six-pack. Image Shocking, right? But it's true.

Visible abs are more about low body fat than strong abdominal muscles.

Various studies have concluded that ab exercises alone don't reduce belly fat or make abs more visible.

So what works? Image
Sep 24, 2024 14 tweets 5 min read
The way Elon Musk runs his companies is insane: 90-hour work weeks. No meetings. No middle management. Hates big teams.

He literally operates six multi-billion dollar companies like startups.

Every entrepreneur needs to understand why it works: 🧵 Image In a recent blog, Paul Graham talked about something known as "Founder mode".

It's essentially being deeply involved in every area of your business.

Elon Musk's deep involvement in the operations of his multiple ventures exemplifies founder mode.

Brian Chesky explains 👇
Sep 17, 2024 17 tweets 5 min read
In 1954, Roger Bannister did the impossible: He ran a mile in under 4 minutes.

But it wasn’t just about speed—it was about unconventional thinking.

Here's how Bannister’s mindset shattered limits and how you can apply it in your own life 🧵 Image Roger Bannister was a British middle-distance runner and a medical student.

Despite a demanding academic schedule, he trained himself and focused on efficiency rather than volume. Image
Sep 12, 2024 18 tweets 5 min read
For a long time, dementia was seen as an inevitable part of aging or the result of poor genetics.

But according to new research:

More than 40% of dementia cases are easily preventable.

Here's what you can do to slow your cognitive decline: Image Dementia is a progressive brain disorder.

It gradually destroys:

- Memory
- Thinking skills
- The ability to perform simple tasks

To this day, it's not curable.

But an ounce of prevention is worth a pound of cure. Thus, let's address the root cause:
Sep 8, 2024 14 tweets 4 min read
Peter Theil says the reason the Paypal mafia exists today isn't because of his hiring techniques but how he managed those people.

Things like extreme bias for action, cult-like company culture, and "one thing" management philosophy. Founders must understand how it works: Image The companies founded by the PayPal Mafia are worth Hundreds of Billions of dollars.

PayPal Mafia's members have gone on to build LinkedIn, SpaceX, YouTube, and other generational companies.

It's no coincidence that all these founders came from a single company. Image
Aug 30, 2024 16 tweets 5 min read
The way that Jensen Huang runs Nvidia is wild: 40 direct reports. No 1:1s. No formal planning cycles. And no status reports.

In a recent interview, he went in-depth on his Leadership style. Every entrepreneur must understand why it works: Image Nvidia’s numbers are so huge it’s hard to understand them on a human scale.

In the first quarter of 2024, they generated $26 billion in revenue, averaging $163.52 million in daily net profit.

That’s ~$1 billion in profit every week. Just insane. Image
Aug 23, 2024 13 tweets 4 min read
In Walter Isaacson's biography of Elon Musk, there's a story of Elon playing poker, where he consistently went all-in until he won.

Peter Thiel says Elon understands risk in ways others don't fully comprehend.

Let me explain: 🧵 Image David Deutsch calls it the Principle of Optimism.

The principle of optimism says that anything not forbidden by the laws of physics is possible with enough knowledge, which can be acquired through trial and error.
Aug 20, 2024 19 tweets 5 min read
Growing a business is not about hustling 24/7.

The real key is something simpler: Laser FOCUS in a world of cheap dopamine hits.

How to protect your focus and avoid distraction: 🧵 Image 1. Wake up without an alarm

Alarm disrupts your sleep cycle and can lead to:

- Sleep inertia
- Drowsiness
- Raised cortisol levels

Also, every time the alarm goes off, your body goes into fight-or-flight mode which is stressful for the body.