In the absence of a time machine, a single cell cannot be tested more than once in a destructive assay. We introduce 'clonal multi-omics' (SIS-seq + SIS-skew) to bypass this challenge and identify Bcor as a negative regulator of dendritic cell fate cell.com/immunity/fullt… Starting in 2012, and what I thought would be wrapped up by 2015, it was a long but ultimately rewarding journey. 3 yrs after our preprint bit.ly/3al3yrH, 2 yrs after @KleinLabHMS seminal state-fate, and @arjunrajlab's recent Rewind, finally out in @ImmunityCP