1/ Happy 50th birthday Inverse Care Law (1971 Julian Tudor Hart). "In areas with most sickness and death, general practitioners have more work, larger lists, less hospital support, and inherit more clinically ineffective traditions of consultation, than in the healthiest areas; 2/ "... and hospital doctors shoulder heavier case-loads with less staff and equipment, more obsolete buildings, and suffer recurrent crises in the availability of beds and replacement staff. These trends can be summed up as the inverse care law:..."

@AdrianHarrop Dear Adrian, I'm sure you wouldn't wish to encourage reckless prescribing. 1/ As with any drug, the harm:benefit ratio depends on indication, dose, time etc. Insulin is vital in Type 1 diabetes, and can be fatal in the well @AdrianHarrop 2/ There is no comparison with menopause guidance nice.org.uk/guidance/ng23. The menopause is not a disease of oestrogen deficiency (but a kind of withdrawal from one normal level to another), there is a LOT of research. @NICEComms