I've made a genetics app, which is designed so that #MECFS & #LongCovid patients can upload a genetics file & it will scan for genetic variants related to my hypothesis which I've developed further over the last year



@lifeanalytics @DanMissailidis

1/10 me-cfs-genetic-analysis.base44.app @lifeanalytics @DanMissailidis The central idea is that oxidised or glycated LDL may undergo excessive phosphatidylcholine (PC) hydrolysis by PLA2 enzymes, producing excess lysophosphatidylcholine (LysoPC).

@JackHadfield14 @Gmwetz @KatBoniface @Dan_Wyke @neurostingl @chydorina @fidjissimo @vijayiyer312

2/10

🚨 Big update to my ME hypothesis!

I've revised my paper to include new insights on the MTHFR gene & how it connects to phosphatidylcholine synthesis.



Here’s a breakdown of what’s new: ⬇️

@JanetDafoe @OxMEDiscovery @PutrinoLab
#MECFS #LongCovid
1/25 Gene variants MTHFR, BHMT & PEMT lead to reduced synthesis of phosphatidylcholine. Even if synthesis is normal, other gene variants could affect transport and membrane uptake of phosphatidylcholine.

@BhupeshPrusty @CortJohnson @angryhacademic @bhanlon15 @sunsopeningband

2/25

🧵 Does Diminished Red Blood Cell Deformability in #MECFS & #LongCovid Affect HbA1c Accuracy?

Last week I discussed with @tessfalor & @RenegadeRes about the possibility of the HbA1C not showing up insulin resistance in #pwME and how this could relate to red blood cells. ⬇️

1/8 Research by Ron Davis @JanetDafoe has shown that #MECFS patients have diminished red blood cell deformability. Could this be affecting the accuracy of the HbA1c test, which relies on healthy red blood cell turnover?

2/8content.iospress.com/articles/clini…

After 2 years of work, here's a video and preprint of my #MECFS #LongCOVID Hypothesis of Insulin Mediated Noradrenergic Neuron Dysfunction!



This builds upon a hypothesis published in the @patientled Hypothesis Journal ⬇️

@JanetDafoe

1/22 The Sympathetic Nervous System is made up of noradrenergic neurons which release norepinephrine.

This hypothesis suggests #MECFS comprises 3 subtypes- 1 involving norepinephrine deficiency & 2 involving reduced expression of the norepinephrine transporter.

@OxMEDiscovery

2/22

@OxMEDiscovery Did you see Maiken Nedergaard's presentation at the NIH ME/CFS Research Roadmap? She discovered the glymphatic system. Her presentation explains at night the brain is washed by CSF flow through the glymphatic system, which is controlled by blood flow, which is controlled by.. @OxMEDiscovery oscillations of norepinephrine. Her presentation is on this link, on the video named Physiology at 2 hours in. Too high or too low norepinephrine is bad for sleep. Depression patients can benefit from drugs that increase norepinephrine, and also can get..

@OxMEDiscovery Thanks for your work, a very interesting paper! You mention impairments of liver associated pathways. Do you know if the metabolites dysregulated in ME/CFS patients would fit with an impairment of hepatic gluconeogenesis? Gluconeogenesis is triggered during exercise and sleep.. @OxMEDiscovery both things that ME/CFS patients have problems with. Also, a recent study showed that ME/CFS patients blood glucose doesn’t rise after exercise, when it does in healthy people. ME/CFS patients also have higher than normal lactate after exercise, as gluconeogenesis is supposed..