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thom Profile picture
thom
@tpq__
MD | PhD | Computational Biologist | CoDA | XAI -omics | Precision Medicine | R-stats | DIY | Vegan | Wu Wei Retweets are not indoor cement
Mar 2, 2020 • 11 tweets • 5 min read
Once again @badlytrainedtec and I have teamed up give you all a new method and R package for compositional data analysis.

How does it work? See below (1/N)

biorxiv.org/content/10.110… @badlytrainedtec CLR and ILR are both popular for compositional data analysis. These are really helpful, but there are limitations. They both use a log-ratio transform of geometric means, and so (a) fail when you have zeros and (b) are not necessarily as interpretable as you think (2/N)