Physician-scientist, oncologist @sloan_kettering. We use fish and human stem cells to study cancer, its developmental origins, and how they metastasize.
Mar 31, 2022 • 15 tweets • 11 min read
A longstanding question in cancer: why do tumors only form in certain locations in the body? In our new @nature paper (nature.com/articles/s4158…), we define anatomic position of the cell as a mechanism for this.
Led by Josh Weiss (@Joshua_M_Weiss), we found that melanomas that arise in different parts of the body have different DNA alterations. These DNA alterations only cause cancer if they synergize with the intrinsic positional gene program present in these different anatomic sites.
