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Andrew Urquhart Profile picture
Andrew Urquhart
@wolfeagle1989
PhD in Space Physics. Hobbyist SARS-CoV-2 lineage hunter. I will block trolls, disinformers, etc at my personal discretion. Also @wolfeagle1989.bksy.social.
Aug 28 • 34 tweets • 10 min read
Dear Secretary @RobertKennedyJr, with your expressed concern about many children now showing signs of mitochondrial dysfunction, here is evidence that a pathogen we continue to allow to circulate without mitigations is known to cause mitochondrial dysfunction: 1/34 Singh et al, "Decoding SARS-CoV-2 hijacking of host mitochondria in COVID-19 pathogenesis", American Journal of Physiology Cell Physiology (2020), 2/34journals.physiology.org/doi/full/10.11…
May 31 • 5 tweets • 3 min read
As NB.1.8.1 “Nimbus” and XFG rise, people need to realize the risk of COVID-induced organ damage in all ages. This graphic is from Ewing et al, “Review of organ damage from COVID and Long COVID: a disease with a spectrum of pathology”, Medical Review, . degruyterbrill.com/document/doi/1…Figure 1 from Ewing et al: 10-30% Long COVID 50% (even as high as 70%) organ damage (both children and adults) Brain: loss of white and grey matter, disruption of blood-brain barrier, loss of learning/memory ability and cognition, autonomic nervous system, ischaemic stroke, intracranial hemorrhage, dementia, Alzheimer’s disease, Parkinson’s disease Heart: Reduced blood oxygen, disruption of chronically inflamed atherosclerotic plaques, infection of coronary vessels, ischaemia, heart attack Endocrine system: direct effects on tissues through ACE2 binding, type 1 and 2 diabetes, Cushing’... To clarify: In the figure, the organ damage percentage is under the Long COVID percentage and applies to those with Long COVID. The source for the finding of up to 70% organ damage for those with Long COVID is Dennis et al, BMJ Open (2021), . 1/3bmjopen.bmj.com/content/11/3/e…
Jan 7 • 14 tweets • 2 min read
For those interested in how SARS-CoV-2 is evolving, I found this paper to be interesting: Furnon et al, “Phenotypic evolution of SARS-CoV-2 spike during the COVID-19 pandemic”, Nature Microbiology,

Some of my notes about this paper: (1/13)nature.com/articles/s4156… “Taken together, these results indicate that the determinants of SARS-CoV-2 virulence are both within and outside of spike” (2/13)
Aug 9, 2024 • 29 tweets • 4 min read
Recently-designated recombinant XEC now leads #Collection42 . XEC is still small, 26 on CoV-Spectrum and 37 on GISAID, but reported from 10 countries on 3 continents with the largest number of sequences from Germany. This one might or might not fade.cov-spectrum.org/collections/42 Searching GISAID for XEC using nucleotide query C18657T, C19716T, C25006T, I now find 50 samples with 2 being pooled US airport traveler surveillance with “GBW-GKP” in the sequence name. 1/15
Oct 12, 2023 • 91 tweets • 9 min read
CoV-Spectrum has loaded new data. As expected, “Pirola” clan JN.1 (BA.2.86.1.1) is climbing on #Collection42 . JN.1 is still small, but growth rate estimates are not driven by a cluster. 1/cov-spectrum.org/collections/42 France has reported the most JN.1 sequences so far (9), but these are spread across 6 French Regions. Also, there are 27 known JN.1 sequences not the 16 found on CoV-Spectrum. 2 of the missing have mangled date information. 9 are too new to be in today’s CoV-Spectrum update. 2/2