Discover and read the best of Twitter Threads about #metabolismclassic
Most recents (1)
Speaking of NAD/NADH (aren't we always?), time to revisit an ultimate #metabolismclassic while I sit at an airport gate: here, a deep dive from Krebs and colleagues dissecting the drivers and implications of the redox ratio in the cytosol and mitochondria pubmed.ncbi.nlm.nih.gov/4291787/ 
First, the premise: understanding the NAD/NADH ratio gives critical insight into what substrates are consumed and why, but it’s not trivial to directly measure these ratios
Next, the demonstration that the NAD/NADH ratio is not the same in the cyto and mito, and that these ratios do not travel together in disease states; broadly, the mito is more reduced than the cytosol
