#COSB_seminar @univienna Nicolas Gompel talks about regulatory evolution underlying wing patterning in insects. #evodevo
Gompel argues, using evidence from the yellow wing spot enhancer, that modular “minimal enhancers” may capture a qualitative pattern but not the quantitative pattern driven by the endogenous gene.
Enhancer modularity is a matter of degree, as binding sites outside the “minimal enhancer” contribute to the pattern, also contributing to other functions, like ubiquitous expression across the wing blade.
Even within enhancers, modularity is relative. Although spacing of transcription factor binding sites is not crucial in this case, spacer sequences contribute to enhancer activities.
Spacer sequences probably important for enhancer accessibility, which may facilitate co-option of novel functions in the vicinity of existing regulatory elements.
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