Mutations in #cancer genomes:
foggy with a chance of thunderstorms⛈️
The @GenomeDataLab describes in @NatureGenet the #mutationfog, which causes hundreds of mutations in each tumor, in some cancers such as lung, head-neck and breast.
➡️bit.ly/3hYOPUC
#IRBScience
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The 'normal' DNA repair process can become coupled to the APOBEC enzyme–typically used by human cells to defend against viruses and trigger this #mutationfog.
Appears to be more active in late-stage metastatic cancers: helps the cancer evolve and resist drugs/radiation.
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@FranSupek: “We think that this APOBEC-driven #mutationfog has a mutagenic potential that matches or even exceeds that of well-known strong carcinogens, such as tobacco smoke or UV radiation. This finding makes APOBEC an attractive target for treating cancer”
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“More than half of all APOBEC mutations in some lung or breast cancers are generated by the hypermutation mechanism that we have found,” says @davidmasp, “understanding APOBEC better could have broad implications for cancer treatment.”
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You can find the paper in @NatureGenet here ➡️nature.com/articles/s4158…
Or read the story here ➡️bit.ly/3hYOPUC
#IRBScience
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