International research centre devoted to curing #cancer and other diseases linked to #aging. @iCERCA center, member of @_BIST.
Apr 25, 2022 • 6 tweets • 7 min read
🔬An international consortium, led by #IRBBarcelona & the biotech company @MerusNV, reports the discovery of MCLA-158, the first clinical candidate screened in #organoids targeting 🎯 #cancer#stemcells of solid tumors.
#IRBScience
Named Petosemtamab, the antibody MCLA-158 prevents the onset of #metastasis (that is, the spread of #cancer to other vital organs) and slows the growth of primary tumours in experimental models of cancer.
Sep 22, 2020 • 4 tweets • 3 min read
#IRBScience: Published in @GenomeMedicine, the latest work from the SBNB lab points to the co-occurrence of #cancer driver genes as a key to precision medicine.
(1/4) Follow this thread to learn more ↘️ #WorldCancerResearchDay
The system is called Targeted Cancer Therapy for You (TCT4U), and it's aimed at predicting tumour response to different treatments.💊
It has allowed the identification of a set of complex biomarkers🧬that have now been made available to the medical-scientific community.
@Eduard_puig is one of the committed scientists who recently made an important contribution to the field.
(1/4)
In June, @Eduard_puig, @SoniaCiudad and Natalia Carulla, among others, revealed the specific ensembles of Aβ protein that have the capacity to disrupt the membrane of neurons, causing their death.
@IRBBarcelona coordinates the European Project Evomet to train 15 young scientists and future leaders in metastasis research with the aim to identify therapeutic solutions. The project has received €4 M and will last for four years.
#IRBScience: The @bbglab publishes "A compendium of mutational cancer driver genes" in @NatureRevCancer, with mportant implications in clinical decision making.
📢568 genes identified with the potential to trigger #cancer!
➡️bit.ly/2DUxvSn
(1/5) @nlbigas@fran_mj88
The study stands on the analysis of the genomes of 28,000 tumours from 66 types of cancer and it's a major update of the #IntOGen platform (intogen.org), aimed at identifying mutational cancer driver genes.
(2/5)
Aug 5, 2020 • 4 tweets • 4 min read
📢TLK protein inhibition activates the innate #ImmuneSystem, thus becoming a potential therapeutic target for enhancing the effect of some #cancer treatments.
➡️bit.ly/2PoObDR #IRBScience
(1/2)
“The activation of innate immunity in cancer has recently become an active area of research as it has become clear that the innate immune response influences chemotherapy and immunotherapy,” comments @genstability, who recently took up a new position at @theNCI.
(2/4)
Aug 4, 2020 • 5 tweets • 5 min read
Les mutacions en el genoma de #càncer:
boira🌫️amb possibilitat de tempesta⛈️
➡️bit.ly/39Svbqs #IRBScience
(1/5)
La #boirademutacions té lloc quan la cèl·lula està en un procés de reparació de l'ADN i, alhora, els enzims APOBEC (per fer front als virus) estan actius.
El procés és més actiu en càncers metastàtics en fase avançada: permetent-los resistir als medicaments i radiació.
(2/5)
Aug 4, 2020 • 5 tweets • 5 min read
Mutations in #cancer genomes:
foggy with a chance of thunderstorms⛈️
The @GenomeDataLab describes in @NatureGenet the #mutationfog, which causes hundreds of mutations in each tumor, in some cancers such as lung, head-neck and breast.
➡️bit.ly/3hYOPUC #IRBScience
(1/5)
The 'normal' DNA repair process can become coupled to the APOBEC enzyme–typically used by human cells to defend against viruses and trigger this #mutationfog.
Appears to be more active in late-stage metastatic cancers: helps the cancer evolve and resist drugs/radiation.
(2/5)
Jul 2, 2020 • 4 tweets • 4 min read
#IRBScience: Did you know that 7% of #cancer cell lines are misclassified and actually correspond to a different type of cancer?
Check out the latest work by the @GenomeDataLab, published in @ScienceAdvances.
➡️bit.ly/3eUx3kh #WomenInSTEM#BigData#MachineLearning
(1/4)
Of 614 cell lines, approx. 60% greatly conserve the characteristics of the tumour of origin, another 20% maintain some resemblance. The remaining 18% differ considerably from the tumour that they supposedly represent. #IRBScience
(2/4)
Jun 25, 2020 • 6 tweets • 6 min read
Researchers from the @bbglab at @IRBBarcelona have contributed to the discovery of #LesionSegregation, explaining how DNA damage caused by chemical mutagens is not repaired immediately and can create more genetic diversity in tumours.
➡️bit.ly/2Nv8u1c
by: @emblebi
(1/5)
The work has been published in the journal @nature.
“This process, which we named #lesionsegregation, is very revealing to understand how mutations occur, a key step in the evolution of cancer,” says @nlbigas.
(2/5)
Se trata de la primera ronda de financiación privada más grande cerrada por una start-up en España.
➡️bit.ly/2CbW4sR
La ronda ha sido liderada por @AsabysPartners y cuenta con la participación de @_AltaLS, @YsiosCapital, FundPlus Belgium y BPI France. La empresa centra su actividad en el desarrollo de un nuevo medicamento para el tratamiento del cáncer metastásico.
Jun 2, 2020 • 4 tweets • 2 min read
The paper "Colibactin DNA-damage signature indicates mutational impact in colorectal cancer", led by Thomas F. Meyer (@mpiib_berlin) and with the collaboration of Federica Battistini and Modesto Orozco at @IRBBarcelona, is now out in @NatureMedicine.
➡️bit.ly/2zSWF1J 1/4
Some bacterial pathogens cause damage in the genomes of infected cells that can lead to the initiation of #cancer. Specifically, this study shows how colibactin, associated with certain strains of E. coli, could create a specific DNA damage in infected human colorectal cells.
2/4
May 1, 2020 • 4 tweets • 5 min read
Hoy es #DíadelTrabajo. Queremos dar las gracias🙏a todas las personas que trabajan en el @IRBBarcelona, por poner tanto esfuerzo y pasión en la ciencia! Gracias a l@s que estas semanas habéis estado al pie del cañón en la lucha contra la #COVID19. #WeAreIRB
Gràcies a tots els #científics i els #tècnics que de forma voluntària han anat a cuidar cada dia els nostres🐀animals i garantir així la nostra #recerca en aquests temps de crisi i confinament. Sense vosaltres l'activitat de l'@IRBBarcelona se n'hagués pogut ressentir. #WeAreIRB
Dec 13, 2019 • 4 tweets • 3 min read
Aquest diumenge 15 de desembre se celebra @la_marato, que aquesta edició serà en benefici de la recerca de les malalties minoritàries. Des de l'@IRBBarcelona ens sumem a l'iniciativa.
Entre tots farem de les minories una majoria!
Vols conèixer els nostres projectes?👇
👨🔬Al lab d'en @xsalvatella1, investigador de l'@IRBBarcelona, estudien la malaltia de Kennedy, una malaltia neuromuscular minoritària causada per una mutació en el receptor d'andrògens. Aquest estiu van identificar una possible diana terapèutica.
➡️irbbarcelona.org/ca/news/invest…
Nov 19, 2019 • 5 tweets • 5 min read
Scientists at @bbglab at @IRBBarcelona have determined for the first time the genetic alterations in the cells of cancer patients that are caused by the main therapies used to treat this disease.👇Read this thread about this study published in @NatureGenet irbbarcelona.org/en/news/geneti…#Chemotherapies have transformed the treatment of #cancer, allowing the survival of many patients. Some of these therapies kill cancer cells by damaging their DNA🧬. However, these drugs can also harm the healthy cells and produce long-term side effects.
Aquest cap de setmana es celebra al Moll de la Fusta la #FestaDeLaCiència⚗️🧪🔬🧬. Un any més, l’@IRBBarcelona participa en aquest esdeveniment amb diverses activitats.
➡️irbbarcelona.org/ca/news/la-tau…
Te les expliquem en aquest fil👇 #TotesSomGenis
El dissabte 26 hi ha 2 tallers per a nens👦👧 d'entre 7 i 12 anys:
✔️Descobreix la química que t'envolta👉 la química està molt present en les nostres vides!!!
✔️El nostre cos, la ciutat perfecta👉descobreix a través del microscopi com son els òrgans del cos. #TotesSomGenis
🧪🧬🔬🌜Avui i demà celebrem la #NitRecerca. No et perdis les activitats que hem preparat a l'@IRBBarcelona per aquesta jornada plena de ciència!👇
Aquesta nit🌜 alguns dels nostres investigadors 👩🔬👨🔬 us explicaran el seu treball de recerca en les microxerrades que tindran lloc a diverses localitzacions de la ciutat. Entra a l'enllaç i hi trobaràs tota la informació.
➡️irbbarcelona.org/en/events/euro…