#IRBScience: The @bbglab publishes "A compendium of mutational cancer driver genes" in @NatureRevCancer, with mportant implications in clinical decision making.
📢568 genes identified with the potential to trigger #cancer!
➡️bit.ly/2DUxvSn
(1/5) @nlbigas @fran_mj88
The study stands on the analysis of the genomes of 28,000 tumours from 66 types of cancer and it's a major update of the #IntOGen platform (intogen.org), aimed at identifying mutational cancer driver genes.
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“The compendium of driver genes provides cancer researchers, both in the clinical and basic research setting, with crucial knowledge and it has an important impact on clinical decision-making,” says @nlbigas, head of the @bbglab at @IRBBarcelona and @icreacommunity.
(3/5)
Most cancer driver genes are highly specific ,capable of triggering only a few tumour types, while a small 2% can drive more than 20.
“Having this snapshot of the compendium has allowed us to address the specificity question in an unbiased way,” says #AbelGonzálezPerez.
(4/5)
“The IntOGen platform provides the ideal infrastructure for the systematic update of the compendium, as more tumour sequencing data are released into the public domain,” says first author @fran_mj88.
(5/5)
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