🔆Decision Algorithm for prescribing #SGLT2i #GLP1RA in #DKD
Ref-CJASN
doi: 10.2215/CJN.02690320
#NephroNotes #Nephpearls #FOAMed #MedTwitter #MedEd
🔆Strategies to ⬇️adverse events in #SGLT2i #GLP1RA
💡Keep genitals dry & clean
💡Prophylactic topical antifungal
💡⬇️Diuretic dose
💡Pt education-"STOP DKA" Protocol
💡Self foot examination
💡Monitor PTH/VitD
doi: 10.2215/CJN.02690320
#NephroNotes #Nephpearls #FOAMed #MedEd
🔆Trials #SGLT2i #GLP1RA
Ref-CJASN
#NephroNotes #FOAMed #MedTwitter #MedEd
🔆Adverse events (vs Placebo) reported with different #SGLT2i
Ref-Expert Opinion on Drug Safety
doi: 10.1080/14740338.2020.1733967
#NephroNotes #Nephpearls #FOAMed #MedTwitter #MedEd
🔆Efficacy of different #SGLT2i
Ref-Expert Opinion on Drug Safety
doi: 10.1080/14740338.2020.1733967
#NephroNotes #Nephpearls #FOAMed #MedTwitter #MedEd
🔆SGLT 1/2 Selectivity of different #SGLT2i
Ref-Diseases
doi: 10.3390/diseases8020014
#NephroNotes #Nephpearls #FOAMed #MedTwitter #MedEd
🔆Extraglycemic effects and Mechanisms: #SGLT2i
Ref-Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
#NephroNotes #Nephpearls #FOAMed #MedTwitter #MedEd
🌸#SGLT2i and Phosphate Homeostasis
Ref-Diabetes & Metabolic Syndrome: Clinical Research & Reviews
doi: 10.1016/j.dsx.2017.08.003
#NephroNotes #Nephpearls #FOAMed #MedTwitter #MedEd
🌸#SGLT2i and Potassium Homeostasis
💡Like ACEI/ARB, SGLT2i ⬆️Potassium but to lower extent
Ref-Diabetes & Metabolic Syndrome: Clinical Research & Reviews
doi: 10.1016/j.dsx.2017.08.003
#NephroNotes #Nephpearls #FOAMed #MedTwitter #MedEd
🌸#SGLT2i and Magnesium Homeostasis
Ref-Diabetes & Metabolic Syndrome: Clinical Research & Reviews
doi: 10.1016/j.dsx.2017.08.003
#NephroNotes #Nephpearls #FOAMed #MedTwitter #MedEd
🌸#SGLT2i ⬆️Sodium in patients with SIADH
👉4 days of Empagliflozin significantly ⬆️ Sodium c/f placebo
👉Profound HypoNa (125 mmol/L) & lower baseline osmolality⬆️ likelihood of response
Ref-JASN
doi: 10.1681/ASN.2019090944
#NephroNotes #Nephpearls #FOAMed #MedEd #MedTwitter
🌸#SGLT2i Mechanism of increased Erythropoietin production
Ref-Circulation
doi: 10.1161/CIRCULATIONAHA.118.038881
#NephroNotes #Nephpearls #FOAMed #MedTwitter #MedEd
🌸 #SGLT2i and Bone Metabolism
Ref-Frontiers in Pharmacology
doi: 10.3389/fphar.2018.01517
#NephroNotes #Nephpearls #FOAMed #MedTwitter #MedEd
🌸 #SGLT2i & Neuropathy
🔥Topic less explored‼️
☄Beneficial in Diabetic peripheral neuropathy
👉Significant⬇️in hypersensitivity response
👉PGP9.5 immunoreactive small nerve loss significantly prevented
Ref-DMJ
doi:10.4093/dmj.2017.0095
#NephroNotes #Nephpearls #FOAMed #MedEd
🌸 #SGLT2i Potential Therapeutic Option in Diabetic Retinopathy‼️
👉Need to explore‼️
#NephroNotes #Nephpearls #FOAMed #MedTwitter #MedEd
🌸 #SGLT2i & Atrial Fibrillation/Flutter in T2DM
☄Dapagliflozin⬇️risk of both 1st & total number of episodes of AF/AFL in T2DM irrespective of prevalence
of AF/ASCVD/HF
Ref-Circulation
doi:10.1161/CIRCULATIONAHA.119.044183
#NephroNotes #Nephpearls #FOAMed #MedTwitter #MedEd
🌸 #SGLT2i and Obesity
☄Empagliflozin ⬇️obesity-
👉⬆️Energy expenditure
👉Adipose tissue browning
👉⬇️Obesity ass inflammation
👉⬇️Insulin resistance
(Alternative macrophage activation)
Ref-BMJ
doi: 10.1136/bmjdrc-2019-000783
#NephroNotes #Nephpearls #FOAMed #MedTwitter #MedEd
🔥 #SGLT2i & Genital Infections
Ref-Int J Diab
#NephroNotes #Nephpearls #FOAMed #MedTwitter #MedEd
🌸 #SGLT2i & Postransplant Diabetes
Ref-Nature Reviews
doi: 10.1038/s41581-019-0173-0
#NephroNotes #Nephpearls #FOAMed #MedTwitter #MedEd
🌸 #SGLT2i & NAFLD/NASH in Diabetes
Ref- Diabetes & Metabolism
doi: 10.1016/j.diabet.2019.01.008
#NephroNotes #Nephpearls #FOAMed #MedTwitter #MedEd
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