Wanted to address question of "should I get vaccinated if I have had #covid19"?. Fair question given that immunity likely long-lived from natural infection per this study from Drs. Weiskopf, Sette, & Shane Crotty from the La Jolla Institute for Immunology
nih.gov/news-events/ni…
And other evidence laid out in this thread. However, I would take the vaccine (1 dose) if I had COVID-19 in the past personally. Why? Because I hate COVID and vax can serve as major immune response booster when a virus is still circulating at high rates
threadreaderapp.com/thread/1368679…
See difference between now & any other time in history is that we are giving out vaccine AS CASES are still circulating high rates. So unprecedented! In fact those who had chickenpox as child (like me, I am old enough!) were not offered VZV vax because I have natural immunity
Re-infection so rare after natural infection but can occur (same with after vax though). You can take one dose because the data is so compelling from great journals that one dose for those who had #covid gives you 10x the antibody response than those not having had #covid19.
Here are 3 papers here - Lancet, JAMA, great journals that 1 dose of mRNA vaccine fine after natural infection in past for high immune responses. papers.ssrn.com/sol3/papers.cf…
jamanetwork.com/journals/jama/…
Another paper from Lancet on this that one dose will give you same immune response as someone who didn't have natural infection & got 2 doses. And evidence that vax helps long covid. So I would take 1 dose if had #covid in past
thelancet.com/journals/lance…
One more paper from NEJM providing evidence that after the administration of a single dose of vaccine, the antibodies against SARS-CoV-2 in people who've had COVID is > response in those without COVID-19 who got 2 doses: nejm.org/doi/full/10.10…
I had tweeted this some time ago regarding if you need vaccine after #covid19 infection. Had suggested 1 dose given studies above & fact that virus still circulating. Now virus circulating much less. This study from Israel shows rate of re-infection
medrxiv.org/content/10.110…
after natural infection vs getting vaccines when cases were (of course) at same level because in same environment. This quite stunning paper from this am in @Nature shows that even with mild infection, develop memory B cells (shown by bone marrow biopsy)
nature.com/articles/s4158…
So, what is my answer? I don't know. If I had COVID in past, I would likely get 1 dose but I will admit this is from emotion more than facts I provided above & in this thread. antibodies don't tell whole story if you are immune (from either prior or vax)
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