A thread on the snippets (paragraphs & quotes) from the book ‘Lifespan’ by David Sinclair @davidasinclair
‘The clock is ticking’
This thread will be updated as I read further & further.
1/ “Every death is violent.” ~ Holocaust documentary filmmaker Claude Lanzmann.
2/ That scene from the film ‘Dead Poets Society’
3/ And Nothing was ever the same again.
The author is talking about 50 extra years of Health-span being the norm.
4/ 400crore years ago, we started with a 2 genes in a single cell with this mechanism👇 to survive, now we are at 21000 genes & 30Trillion cells.
5/ We are the great survivors.
6/ Car T-cell therapy explained: Expected to grow at 45%+ for the next 7 years 🚀
7/ Consuming products filled with antioxidants does no good. It’s a marketing gimmick.
8/ How the scientists will push back death.
9/ There are 2 types of information in our cells: Digital (Genome) & Analog (Epigenome)
Simpler explanation for Epigentics: explains how nuture (not nature) leads to changes in your DNA.
Simply, how 2 twins which have the same genes can have diametrically opposite lives.
10/ Why people who exercise or fast seem younger: Hormesis.
11/ That’s what is humbling about nature: something like yeast that is used in brewing beer can also help cure cancer.
12/ Why Yeast? 😉
13/ epigenome’s design.
14/ Simplest explanation of the epigenome: its melodious.
15/ A caterpillar can’t transform to a human, but only into a butterfly: Why the genome is equally important.
16/ “Studies of identical twins place the genetic influences on longevity at between 10 and 25 percent which by any estimation is surprisingly low.”
Our DNA is not our destiny.
17/ From learning from yeast to learning from trees. I am sensing a pattern here.
18/ Real Life terminators.
19/ Aging is a disease.
20/ This is what being old feels like physically.
21/ We are living longer, but at what cost.
22/ Cigarette smoking increases chances of developing lung cancer by 5x. Here’s how it works 👇
23/ “Though smoking increases the risk of getting cancer by fivefold, being 50 years old increases your cancer risk hundred fold. By the age of 70, it’s a thousand fold.
Not just cancer, valid for heart disease. And Diabetes. And Dementia. The list goes on & on.”
24/ It’s that simple.
25/ The 1st & most probably the last genuine Self Help guy.
26/ Intermittent fasting (IF) works.
“Go hungry for an entire week every quarter.” ~ @PeterAttiaMD
27/ Your diet probably needs to look a lot like a rabbit’s lunch than a lion’s dinner.
28/ Something in which protein shake drinkers be interested in.
29/ Wear one less sweater to live longer.
30/ Once you understand how cells actually work, they are the most amazing things.
31/ The possibilities with Gene Therapy 🧬 are 🤯
32/ ‘Precision medicine’ is catching up.
Not just what works for most people most of the time.
33/ The power of precision medicine & why do we need it.
34/‘It won’t be long before prescribing a drug without first knowing a patient’s genome will seem medieval.’
Enter Pharmocoepigenetics: We all don’t respond to medicines in the same way.
35/ The book predicted the current Pandemic.
36/ “Epidemiologists say a fast moving airborne pathogen will kill more than 30 million people in less than a year and they say that there is a reasonable probability that the world will experience such an outbreak in the next 10-15 years.” ~ Bill Gates in 2017.
37/ Be careful what you wish for.
38/ Even Nobel Laureates & Billionaires can underestimate compounding. The thing that differentiates us & them is that they are quick to change lanes.
39/ Reminds me of Anton Ego’s speech in the Pixar movie ‘Ratatouille’:
40/ Start working on getting rich if you want to live longer.
41/ All the age related advances in the next decades will be expensive.
42/ This will happen when we face a population explosion 🚀
43/ “In 1800, the global literacy rate was 12%, by 1900 and it was 21% & today it’s 85%. We now live in a world where more than 4 out of 5 people can read, the majority of whom have instant access to essentially all the world‘s knowledge.”
44/ This is something to watch out for: the working age population crisis in most countries could be solved.
45/ If you think extending your lifespan isn’t for you, Read this.
46/ A dab of optimism goes a long way in the discovery of the new 💫
Wish I read this book earlier.
Time to make some changes to the epigenome.
Aging is a disease. (X9999)
End of Thread.
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